Antimicrobial resistance is a global threat that kills at least 75,000 people every year worldwide and causes extended hospital stays. In the coming 10 years, antimicrobial resistance is projected to have huge health and economic burden on countries, and the scarcity of available antibiotics further worsens the situation. Antimicrobial resistance results mainly from indiscriminate antibiotic usage in humans, animals and agriculture, and from the rapid emergence and dissemination of resistant pathogens. This issue is challenging for antibiotic stewardship, strict regulations on antibiotics usage, large-scale surveillance and responsible public behavior. This demands international cooperation and integrated efforts under the ‘one-health’ strategy. Here, we review antimicrobial resistance and the one-health strategy. We discuss the historical issue of using antibiotics. We highlight the effectiveness of hygiene in livestock rearing, careful antibiotic usage and large-scale surveillance of animals, humans and environment domains. We present strategies for mitigation of antimicrobial resistance, exemplified by the successful ban of triclosan which induced a significant decline of resistant pathogens. We emphasize the benefits of the global antibiotic resistance partnership and of the one-health participation of stakeholders from public, healthcare professionals and government to mitigate antimicrobial resistance.

抗菌素耐药性是全球性威胁，全世界每年至少杀死75,000人，并导致长期住院。预计在未来十年中，抗菌素耐药性将给各国带来巨大的健康和经济负担，而可用抗生素的匮乏将使情况进一步恶化。抗菌素耐药性主要是由于在人类，动物和农业中不加选择地使用抗生素，以及耐药性病原体的迅速出现和传播。这个问题对抗生素管理，对抗生素使用的严格规定，大规模监测和负责任的公众行为具有挑战性。这就要求在“一站式”战略下进行国际合作和作出综合努力。在这里，我们回顾了抗菌素耐药性和一种健康策略。我们讨论使用抗生素的历史问题。我们强调了卫生在畜牧饲养，谨慎使用抗生素以及对动物，人类和环境领域进行大规模监视方面的有效性。我们提出了减轻抗菌素耐药性的策略，以成功禁用三氯生为例，这会导致耐药性病原体的大量减少。我们强调全球抗药性耐药性合作伙伴关系以及公众，卫生保健专业人员和政府利益相关者的一站式参与以减轻抗药性耐药性的好处。以成功禁用三氯生为例，这会导致耐药病原体的大量减少。我们强调全球抗药性耐药性合作伙伴关系以及公众，卫生保健专业人员和政府利益相关者的一站式参与以减轻抗药性耐药性的好处。以成功禁用三氯生为例，这会导致耐药病原体的大量减少。我们强调全球抗药性耐药性合作伙伴关系以及公众，卫生保健专业人员和政府利益相关者的一站式参与以减轻抗药性耐药性的好处。