MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies.

中文翻译：

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多囊卵巢综合征患者卵巢颗粒细胞中 miR-188-3p 增加

MicroRNA 目标网络在疾病中经常失调。我们的目的是调查这种多囊卵巢综合征 (PCOS) 的失调。通过对公共RNAseq数据集的生物信息学再分析，我们发现miR-188-3p是诱导率最高的miRNA，表明miR-188-3p可能具有罕见的上调其靶向表达的功能。这一发现将增加我们对 PCOS 病理学的理解，并为治疗策略提供新的目标。