Highly hydrophilic magnetic molecularly imprinted polymers were prepared through a surface imprinting technique for dispersive solid-phase extraction coupled with high-performance liquid chromatography to detect trace levels of ten sulfonamides in animal-derived samples. The obtained imprinted polymers were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and adsorption experiments, which exhibited excellent specific adsorption for template sulfamethazine in aqueous solution. Moreover, the adsorption process could be completed within 25 min. Under the optimum conditions, the method exhibits good linear performance in the range of 5–to 10 mg/L, limits of detection ranging from 0.57 to 1.50 μg/L, and good recoveries of 85.09–110.93% in the spiked samples (chicken, cow milk, and goat milk). The proposed detection method not only avoids the use of organic solvents but also simplifies the pretreatment procedure via excellent magnetic properties. Furthermore, the method shows great potential for the rapid detection of drug residues.

中文翻译：

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开发亲水性磁性分子印迹聚合物，用于在 HPLC 检测前从动物源样品中分散固相萃取磺胺

通过表面印迹技术制备高亲水性磁性分子印迹聚合物，用于分散固相萃取与高效液相色谱相结合，以检测动物源样品中痕量水平的十种磺胺。所得印迹聚合物通过傅里叶变换红外光谱、扫描电子显微镜、热重分析和吸附实验进行表征，对水溶液中的模板剂磺胺二甲嘧啶表现出优异的特异性吸附。此外，吸附过程可以在 25 分钟内完成。在最佳条件下，该方法在 5-10 mg/L 范围内表现出良好的线性，检测限范围为 0.57-1.50 μg/L，加标样品（鸡、牛奶，和山羊奶）。所提出的检测方法不仅避免了有机溶剂的使用，而且通过优异的磁性简化了预处理程序。此外，该方法显示出快速检测药物残留的巨大潜力。