Abstract

In this study, the cationic monomer [2-(acryloyloxy)ethyl]trimethylammonium chloride solution (AETAC) and vinyl imidazole (VI) were used with the free radical polymerization technique, which is a simple and rapid synthesis method, to synthesize p(AETAC-co-VI) hydrogels. To increase the density of cationic charge on the hydrogel, it underwent the protonation process with HCl. The obtained p(AETAC-co-VI)/Q hydrogel was modified with Au nanoparticles to increase bactericidal effect to obtain the AuNPs/p(AETAC-co-VI)/Q nanocomposite hydrogel. The morphology and chemical structure of the hydrogels were characterized with SEM and FTIR. Additionally, the swelling capabilities were tested in different pH media. XRD and TEM confirmed the formation of the nanocomposite hydrogel. The antibacterial activity of the hydrogels was tested against E. coli and S. aureus, and controlled release implementations were completed with sodium diclofenac (NaDc) drug. The NaDc drug release profiles of the hydrogels were researched using the Korsmeyer–Peppas model at 37 °C in different simulated buffer (pH 6.0, 7.2, and 8.0) solutions. It was found that both the hydrogel and nanocomposite hydrogel followed non-Fickian diffusion mechanisms as free release mechanism. Here, the maximum drug release efficacy was found to be 97%, and drug release was more rapid in basic media when release media were compared. The AuNPs/p(AETAC-co-VI)/Q nanocomposite hydrogels produced in this study with advanced antibacterial features were suitable for recommendation as good carriers for in vitro release of NaDc drugs in areas like the biomedical and pharmaceutical industries.

Graphical abstract

中文翻译：

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AuNPs / p（AETAC-co-VI）/ Q纳米复合水凝胶的合成，表征和体外药物释放特性

摘要

在这项研究中，阳离子自由基单体[2-（丙烯酰氧基）乙基]三甲基氯化铵溶液（AETAC）和乙烯基咪唑（VI）与自由基聚合技术一起使用，这是一种简单，快速的合成方法，可以合成p（AETAC -co-VI）水凝胶。为了增加水凝胶上阳离子电荷的密度，它经过了HCl的质子化过程。用Au纳米粒子修饰获得的p（AETAC-co-VI）/ Q水凝胶，以提高杀菌效果，得到AuNPs / p（AETAC-co-VI）/ Q纳米复合水凝胶。用SEM和FTIR对水凝胶的形貌和化学结构进行了表征。另外，在不同的pH介质中测试了溶胀能力。XRD和TEM证实了纳米复合水凝胶的形成。测试了水凝胶的抗菌活性大肠杆菌和金黄色葡萄球菌，并使用双氯芬酸钠（NaDc）药物完成了控释实施。使用Korsmeyer-Peppas模型在37°C的不同模拟缓冲液（pH 6.0、7.2和8.0）溶液中研究了水凝胶的NaDc药物释放曲线。发现水凝胶和纳米复合水凝胶均遵循非菲克扩散机制作为自由释放机制。在这里，发现最大的药物释放效率为97％，当比较释放介质时，药物在碱性介质中的释放更为迅速。在这项研究中生产的具有先进抗菌功能的AuNPs / p（AETAC-co-VI）/ Q纳米复合水凝胶适合作为生物医学和制药等领域中NaDc药物体外释放的良好载体。

图形概要