Specificity and sensitivity in biochemical reactions can be achieved through regulation of equilibrium binding affinity or through proofreading mechanisms that allow for the dissociation of unwanted intermediates. In this essay, we aim to provide our perspectives on how the concept of kinetic proofreading might apply in the context of cargo sorting in clathrin-mediated endocytosis.

中文翻译：

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网格蛋白组装和内吞货物分选的动力学视图

生化反应的特异性和敏感性可以通过调节平衡结合亲和力或通过允许分离不需要的中间体的校对机制来实现。在本文中，我们旨在就动力学校对的概念如何应用于网格蛋白介导的内吞作用中的货物分选提供我们的观点。