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Nitrogen-Neutral Amino Acids Refinery: Deamination of Amino Acids for Bio-Alcohol and Ammonia Production
ChemBioEng Reviews ( IF 4.8 ) Pub Date : 2021-04-14 , DOI: 10.1002/cben.202000031
Kwon‐Young Choi 1
Affiliation  

Amino acids are a valuable bioresource that contains both the acid form of carbon and the amine group of nitrogen. Amino acids not only constitute proteins and the building blocks for living organisms but also provide a key intermediate for controlling the nitrogen balance in cells. The production of amino acids using microorganisms has, along with the development of biotechnology, created a large market for biochemicals. In parallel, there have been various biochemical production methods using pulmonary proteins or direct amino acids as biomass through enzymatic bioconversion or whole-cell biotransformation. The deamination of amino acids facilitated the applications of 2-keto and acrylic acids, in particular, for biofuels of bio alcohol, pharmaceuticals, cosmetics, as building blocks for polymers, and other versatile industrial chemicals. In this review, we report on the application of amino acids derived from biochemicals initiated by deamination reactions using deaminase, ammonia-lyase, and oxidase enzymes for biotechnology applications.

中文翻译:

氮中性氨基酸精炼厂:用于生物酒精和氨生产的氨基酸脱氨

氨基酸是一种宝贵的生物资源,它同时包含碳的酸形式和氮的胺基。氨基酸不仅构成蛋白质和生物体的组成部分,而且还是控制细胞中氮平衡的关键中间体。利用微生物生产氨基酸,随着生物技术的发展,为生化产品创造了巨大的市场。与此同时,通过酶促生物转化或全细胞生物转化,使用肺蛋白质或直接氨基酸作为生物质的各种生化生产方法已经出现。氨基酸的脱氨基促进了 2-酮和丙烯酸的应用,特别是用于生物醇、药物、化妆品的生物燃料,作为聚合物和其他通用工业化学品的构建块。
更新日期:2021-06-15
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