Orthostatic hypotension (OH) is relatively common in the early stage of Parkinson’s disease (PD). It is divided into delayed OH and classical OH. Classical OH in PD has been investigated widely, however, the clinical implications of delayed OH in PD have seldom been studied. The purpose of this study is to characterize delayed OH in PD. A total of 285 patients with early drug-naïve PD were enrolled and divided into three groups according to orthostatic change: no-OH, delayed OH, and classical OH. The disease severity in terms of motor, non-motor, and cognitive functions was assessed. The cortical thickness of 82 patients was analyzed with brain magnetic resonance imaging. The differences among groups and linear tendency in the order of no-OH, delayed OH, and classical OH were investigated. Seventy-seven patients were re-evaluated. Initial and follow-up evaluations were explored to discern any temporal effects of orthostasis on disease severity. Sixty-four (22.5%) patients were defined as having delayed OH and 117 (41.1%) had classical OH. Between-group comparisons revealed that classical OH had the worst outcomes in motor, non-motor, cognitive, and cortical thickness, compared to the other groups. No-OH and delayed OH did not differ significantly. Linear trends across the pre-ordered OH subtypes found that clinical parameters worsened along with the orthostatic challenge. Clinical scales deteriorated and the linear gradient was maintained during the follow-up period. This study suggests that delayed OH is a mild form of classical OH in PD. PD with delayed OH has milder disease severity and progression.

体位性低血压（OH）在帕金森氏病（PD）的早期阶段相对常见。它分为延迟OH和经典OH。PD中的经典OH已得到广泛研究，但很少研究PD中延迟OH的临床意义。这项研究的目的是表征PD中延迟的OH。总共招募了285名初次药物治疗的PD患者，并根据体位性变化将其分为三类：无OH，延迟OH和经典OH。评估了运动，非运动和认知功能方面的疾病严重程度。通过脑磁共振成像分析了82例患者的皮层厚度。研究了不同组之间的差异以及按no-OH，延迟OH和经典OH顺序排列的线性趋势。对77例患者进行了重新评估。探索初步和后续评估，以了解矫正对疾病严重程度的任何时间影响。六十四（22.5％）例患者被定义为延迟性OH，117例（41.1％）患者为经典性OH。组间比较显示，与其他组相比，经典OH在运动，非运动，认知和皮层厚度方面的结果最差。No-OH和延迟的OH没有显着差异。预定的OH亚型的线性趋势发现，随着体位性挑战，临床参数恶化。临床量表恶化，在随访期间保持线性梯度。这项研究表明，延迟OH是PD中经典OH的一种温和形式。OH延迟的PD具有较轻的疾病严重度和进展。