Although the role of dopamine (DA) in malignant tumors has been reported, its function in premalignant lesions is unknown. Herein we report that the stimulation of DA D2 receptors in endothelial cells in ultraviolet B (UVB)-induced cutaneous lesions in mice significantly reduced the tumor number, tumor burden, and malignant squamous cell carcinoma in these animals. DA D2 receptor agonist inhibited VEGFA-dependent proangiogenic genes in vitro and in vivo . However, the mice pretreated with selective DA D2 receptor antagonist inhibited the actions of the agonist, thereby suggesting that the action of DA was through its D2 receptors in the endothelial cells. To our knowledge, this study is the first to report DA-mediated regulation of pathogenesis and progression of UVB-induced premalignant skin lesions. Prevention Relevance: This investigation demonstrates the role of dopamine and its D2 receptors in UVB induced premalignant squamous cell skin lesions and how DA through its D2 receptors inhibits the development and progression of these lesions and subsequently prevents squamous cell carcinoma of the skin.

中文翻译：

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多巴胺通过其 D2 受体防止紫外线 B 诱导的癌前皮肤病变的发展和进展

尽管已经报道了多巴胺（DA）在恶性肿瘤中的作用，但其在癌前病变中的作用尚不清楚。在这里，我们报告在紫外线 B (UVB) 诱导的小鼠皮肤损伤中刺激内皮细胞中的 DA D2 受体显着减少了这些动物的肿瘤数量、肿瘤负荷和恶性鳞状细胞癌。DA D2 受体激动剂在体外和体内抑制 VEGFA 依赖性促血管生成基因。然而，用选择性DA D2受体拮抗剂预处理的小鼠抑制了激动剂的作用，从而表明DA的作用是通过其在内皮细胞中的D2受体。据我们所知，这项研究是第一个报告 DA 介导的 UVB 诱导的癌前皮肤病变的发病机制和进展的调节。预防相关：