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Morphologically homogeneous, pH-responsive gold nanoparticles for non-invasive imaging of HeLa cancer
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 5.4 ) Pub Date : 2021-04-13 , DOI: 10.1016/j.nano.2021.102394
Min Su Yim 1 , Yeon Sil Hwang 1 , Jeong Kyu Bang 2 , Dae-Woong Jung 3 , Jun Min Kim 3 , Gi-Ra Yi 4 , Gaehang Lee 5 , Eun Kyoung Ryu 2
Affiliation  

Gold nanoparticles (AuNPs) have been widely used as nanocarriers in drug delivery to improve the efficiency of chemotherapy treatment and enhance early disease detection. The advantages of AuNPs include their excellent biocompatibility, easy modification and functionalization, facile synthesis, low toxicity, and controllable particle size. This study aimed to synthesize a conjugated citraconic anhydride link between morphologically homogeneous AuNPs and doxorubicin (DOX) (DOX-AuNP). The carrier was radiolabeled for tumor diagnosis using positron emission tomography (PET). The systemically designed DOX-AuNP was cleaved at the citraconic anhydride linker site under the mild acidic conditions of a cancer cell, thereby releasing DOX. Subsequently, the AuNPs aggregated via electrostatic attraction. HeLa cancer cells exhibited a high uptake of the radiolabeled DOX-AuNP. Moreover, PET tumor images were obtained using radiolabeled DOX-AuNP in cancer xenograft mouse models. Therefore, DOX-AuNP is expected to provide a valuable insight into the use of radioligands to detect tumors using PET.



中文翻译:

用于 HeLa 癌症无创成像的形态均质、pH 响应性金纳米粒子

金纳米粒子(AuNPs)已被广泛用作药物递送中的纳米载体,以提高化疗治疗的效率并增强早期疾病检测。AuNPs具有生物相容性好、易于修饰和功能化、合成简便、毒性低、粒径可控等优点。本研究旨在合成形态均一的 AuNPs 和多柔比星 (DOX) (DOX-AuNP) 之间的共轭柠康酸酐连接。使用正电子发射断层扫描 (PET) 对载体进行放射性标记以用于肿瘤诊断。在癌细胞的温和酸性条件下,系统设计的 DOX-AuNP 在柠康酸酐接头位点被切割,从而释放 DOX。随后,AuNPs通过聚合静电引力。HeLa 癌细胞表现出对放射性标记的 DOX-AuNP 的高摄取。此外,在癌症异种移植小鼠模型中使用放射性标记的 DOX-AuNP 获得 PET 肿瘤图像。因此,DOX-AuNP 有望为使用放射性配体使用 PET 检测肿瘤提供有价值的见解。

更新日期:2021-05-06
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