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Progress in Defining the Genetic Contribution to Type 2 Diabetes in Individuals of East Asian Ancestry
Current Diabetes Reports ( IF 4.2 ) Pub Date : 2021-04-13 , DOI: 10.1007/s11892-021-01388-2
Cassandra N. Spracklen , Xueling Sim

Purpose of Review

Prevalence of type 2 diabetes (T2D) and progression of complications differ between worldwide populations. While obesity is a major contributing risk factor, variations in physiological manifestations, e.g., developing T2D at lower body mass index in some populations, suggest other contributing factors. Early T2D genetic associations were mostly discovered in European ancestry populations. This review describes the progression of genetic discoveries associated with T2D in individuals of East Asian ancestry in the last 10 years and highlights the shared genetic susceptibility between the population groups and additional insights into genetic contributions to T2D.

Recent Findings

Through increased sample size and power, new genetic associations with T2D were discovered in East Asian ancestry populations, often with higher allele frequencies than European ancestry populations.

Summary

As we continue to generate maps of T2D-associated variants across diverse populations, there will be a critical need to expand and diversify other omics resources to enable integration for clinical translation.



中文翻译:

定义东亚先祖个体对2型糖尿病的遗传贡献的研究进展

审查目的

世界各地的人群之间,2型糖尿病(T2D)的患病率和并发症的进展有所不同。肥胖是主要的致病因素,但生理表现的变化(例如,某些人群在较低的体重指数下发展为T2D)提示其他致病因素。早期的T2D遗传关联主要在欧洲血统人群中发现。这篇综述描述了过去10年中东亚血统个体中与T2D相关的遗传发现的进展,并强调了人群之间共有的遗传易感性以及对T2D遗传贡献的其他见解。

最近的发现

通过增加样本量和能力,在东亚血统人群中发现了与T2D的新遗传关联,其等位基因频率通常高于欧洲血统人群。

概括

随着我们继续生成跨不同人群的T2D相关变体的图谱,迫切需要扩展和多样化其他组学资源以实现临床翻译的整合。

更新日期:2021-04-13
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