Although widely used in the evaluation of the diseased, normal intracranial pressure and lumbar cerebrospinal fluid pressure remain sparsely documented. Intracranial pressure is different from lumbar cerebrospinal fluid pressure. In addition, intracranial pressure differs considerably according to the body position of the patient. Despite this, the current reference values do not distinguish between intracranial and lumbar cerebrospinal fluid pressures, and body position-dependent reference values do not exist. In this study, we aim to establish these reference values. A systematic search was conducted in MEDLINE, EMBASE, CENTRAL, and Web of Sciences. Methodological quality was assessed using an amended version of the Joanna Briggs Quality Appraisal Checklist. Intracranial pressure and lumbar cerebrospinal fluid pressure were independently evaluated and subdivided into body positions. Quantitative data were presented with mean ± SD, and 90% reference intervals. Thirty-six studies were included. Nine studies reported values for intracranial pressure, while 27 reported values for the lumbar cerebrospinal fluid pressure. Reference values for intracranial pressure were − 5.9 to 8.3 mmHg in the upright position and 0.9 to 16.3 mmHg in the supine position. Reference values for lumbar cerebrospinal fluid pressure were 7.2 to 16.8 mmHg and 5.7 to 15.5 mmHg in the lateral recumbent position and supine position, respectively. This systematic review is the first to provide position-dependent reference values for intracranial pressure and lumbar cerebrospinal fluid pressure. Clinically applicable reference values for normal lumbar cerebrospinal fluid pressure were established, and are in accordance with previously used reference values. For intracranial pressure, this study strongly emphasizes the scarcity of normal pressure measures, and highlights the need for further research on the matter.

中文翻译：

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颅内压和腰椎脑脊液压力的参考值：系统评价

尽管正常颅内压和腰椎脑脊液压力广泛用于评估患病者，但其记录仍然很少。颅内压与腰椎脑脊液压不同。此外，颅内压根据患者的体位而有很大差异。尽管如此，目前的参考值并没有区分颅内和腰椎脑脊液压力，并且不存在与体位相关的参考值。在本研究中，我们的目标是建立这些参考值。在 MEDLINE、EMBASE、CENTRAL 和 Web of Sciences 上进行了系统检索。使用乔安娜·布里格斯质量评估清单的修订版来评估方法学质量。独立评估颅内压和腰椎脑脊液压力并细分为体位。定量数据以平均值±SD 和 90% 参考区间表示。纳入了三十六项研究。9 项研究报告了颅内压值，27 项研究报告了腰椎脑脊液压力值。直立位时颅内压的参考值为-5.9至8.3mmHg，仰卧位时颅内压的参考值为0.9至16.3mmHg。侧卧位和仰卧位腰椎脑脊液压力的参考值分别为7.2～16.8 mmHg和5.7～15.5 mmHg。这项系统评价首次为颅内压和腰椎脑脊液压力提供位置相关的参考值。建立了临床适用的正常腰椎脑脊液压力参考值，并与以前使用的参考值一致。对于颅内压，本研究强烈强调了正常压力测量的稀缺性，并强调了对此问题进行进一步研究的必要性。