当前位置: X-MOL 学术J. of Cardiovasc. Trans. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impact of Chronic Kidney Disease and Platelet Reactivity on Clinical Outcomes Following Percutaneous Coronary Intervention
Journal of Cardiovascular Translational Research ( IF 3.4 ) Pub Date : 2021-04-13 , DOI: 10.1007/s12265-021-10126-8
Fabio Mangiacapra 1 , Alessandro Sticchi 1 , Edoardo Bressi 1 , Roberto Mangiacapra 2, 3 , Michele Mattia Viscusi 1 , Iginio Colaiori 1 , Elisabetta Ricottini 1 , Ilaria Cavallari 1 , Silvia Spoto 4 , Gian Paolo Ussia 1 , Pietro Manuel Ferraro 2, 3 , Francesco Grigioni 1
Affiliation  

We investigated the interaction between chronic kidney disease (CKD) and high platelet reactivity (HPR) in determining long-term clinical outcomes following elective PCI for stable coronary artery disease (CAD). A total of 500 patients treated with aspirin and clopidogrel were divided based on the presence of CKD (defined as glomerular filtration rate of < 60 ml/min/1.73 m2) and HPR (defined as a P2Y12 reaction unit value ≥ 240 at VerifyNow assay). Primary endpoint was the occurrence of major adverse clinical events (MACE) at 5 years. Patients with both CKD and HPR showed the highest estimates of MACE (25.6%, p = 0.005), all-cause death (17.9%, p = 0.004), and cardiac death (7.7%, p = 0.004). The combination of CKD and HPR was an independent predictor of MACE (HR 3.12, 95% CI 1.46–6.68, p = 0.003). In conclusion, the combination of CKD and HPR identifies a cohort of patients with the highest risk of MACE at 5 years.



中文翻译:

慢性肾脏病和血小板反应性对经皮冠状动脉介入治疗后临床结果的影响

我们研究了慢性肾脏病 (CKD) 和高血小板反应性 (HPR) 之间的相互作用,以确定稳定性冠状动脉疾病 (CAD) 选择性 PCI 后的长期临床结果。共有 500 名接受阿司匹林和氯吡格雷治疗的患者根据 CKD(定义为肾小球滤过率 < 60 ml/min/1.73 m 2)和 HPR(在 VerifyNow 测定中定义为 P2Y12 反应单位值 ≥ 240)进行分类)。主要终点是 5 年主要不良临床事件 (MACE) 的发生。CKD 和 HPR 患者的 MACE(25.6%,p = 0.005)、全因死亡(17.9%,p = 0.004)和心源性死亡(7.7%,p= 0.004)。CKD 和 HPR 的组合是 MACE 的独立预测因子(HR 3.12, 95% CI 1.46–6.68, p = 0.003)。总之,CKD 和 HPR 的组合确定了一组 5 年时 MACE 风险最高的患者。

更新日期:2021-04-13
down
wechat
bug