Several studies have recently described 4-repeat tauopathies that are characterized by the presence of globular glial inclusions. These inclusions are astrocytic or oligodendroglial, show extensive white matter involvement, and have a wide range of neuropathological and clinical presentations. Globular glial tauopathy (GGT) is classified into three subtypes according to clinical manifestations. Type I is characterized by frontotemporal lobar degeneration and represents a group of diseases with diverse clinical and histopathological features. Some of these disorders are associated with abnormal microtubule-associated protein tau gene. Type II presents as motor impairment due to pyramidal involvement, whereas type III is a combination of the features of types I and II. This report describes a rare case of GGT that manifested as depression and anxiety and demonstrates its neuropathological features. We have also compared the features of this case with those of previously reported cases and have revisited the classification.

中文翻译：

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球状胶质 tau 蛋白病，一种新发现的白质 tau 蛋白病，伴有抑郁/焦虑症：分类报告和审查

最近有几项研究描述了 4 重复 tauopathies，其特征是存在球状胶质内含物。这些包涵体是星形胶质细胞或少突胶质细胞，显示广泛的白质受累，并具有广泛的神经病理学和临床表现。球状胶质tau蛋白病（GGT）根据临床表现分为三个亚型。I 型以额颞叶变性为特征，代表一组具有不同临床和组织病理学特征的疾病。其中一些疾病与异常的微管相关蛋白 tau 基因有关。II 型表现为由于锥体受累引起的运动障碍，而 III 型是 I 型和 II 型特征的组合。本报告描述了一个罕见的 GGT 病例，表现为抑郁和焦虑，并展示了其神经病理学特征。我们还将此病例的特征与先前报告的病例的特征进行了比较，并重新审视了分类。