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The Relationship Between Walking Speed and the Energetic Cost of Walking in Persons With Multiple Sclerosis and Healthy Controls: A Systematic Review
Neurorehabilitation and Neural Repair ( IF 4.2 ) Pub Date : 2021-04-13 , DOI: 10.1177/15459683211005028
Kyra Theunissen 1, 2, 3 , Guy Plasqui 1 , Annelies Boonen 2 , Bente Brauwers 1 , Annick Timmermans 3 , Pieter Meyns 3 , Kenneth Meijer 1 , Peter Feys 3, 4
Affiliation  

Background

Persons with multiple sclerosis (pwMS) experience walking impairments, characterized by decreased walking speeds. In healthy subjects, the self-selected walking speed is the energetically most optimal. In pwMS, the energetically most optimal walking speed remains underexposed. Therefore, this review aimed to determine the relationship between walking speed and energetic cost of walking (Cw) in pwMS, compared with healthy subjects, thereby assessing the walking speed with the lowest energetic cost. As it is unclear whether the Cw in pwMS differs between overground and treadmill walking, as reported in healthy subjects, a second review aim was to compare both conditions.

Method

PubMed and Web of Science were systematically searched. Studies assessing pwMS, reporting walking speed (converted to meters per second), and reporting oxygen consumption were included. Study quality was assessed with a modified National Heart, Lung and Blood Institute checklist. The relationship between Cw and walking speed was calculated with a second-order polynomial function and compared between groups and conditions.

Results

Twenty-nine studies were included (n = 1535 pwMS) of which 8 included healthy subjects (n = 179 healthy subjects). PwMS showed a similar energetically most optimal walking speed of 1.44 m/s with a Cw of 0.16, compared with 0.14 mL O2/kg/m in healthy subjects. The most optimal walking speed in treadmill was 1.48 m/s, compared with 1.28 m/s in overground walking with a similar Cw.

Conclusion

Overall, the Cw is elevated in pwMS but with a similar energetically most optimal walking speed, compared with healthy subjects. Treadmill walking showed a similar most optimal Cw but a higher speed, compared with overground walking.



中文翻译:

多发性硬化症和健康对照者步行速度与步行能量消耗之间的关系:系统评价

背景

患有多发性硬化症 (pwMS) 的人会出现行走障碍,其特征是行走速度降低。在健康受试者中,自我选择的步行速度是能量上最优化的。在 pwMS 中,能量最佳的步行速度仍然曝光不足。因此,本综述旨在确定 pwMS 中步行速度与步行能量消耗 (Cw) 之间的关系,与健康受试者相比,从而评估能量消耗最低的步行速度。由于不清楚 pwMS 中的 Cw 在地上行走和跑步机行走之间是否存在差异,正如健康受试者所报告的那样,第二个审查目的是比较这两种情况。

方法

系统搜索了 PubMed 和 Web of Science。包括评估 pwMS、报告步行速度(转换为米/秒)和报告耗氧量的研究。研究质量通过修改后的国家心肺血液研究所检查表进行评估。使用二阶多项式函数计算 Cw 与步行速度之间的关系,并在组和条件之间进行比较。

结果

纳入了 29 项研究(n = 1535 pwMS),其中 8 项包括健康受试者(n = 179 名健康受试者)。与健康受试者的0.14 mL O 2 /kg/m相比,PwMS 显示出相似的能量最佳步行速度为 1.44 m/s,Cw 为 0.16 。在跑步机上的最佳步行速度为 1.48 m/s,而在具有相似 Cw 的地上步行中为 1.28 m/s。

结论

总体而言,与健康受试者相比,pwMS 中的 Cw 升高,但具有相似的能量最佳步行速度。与地上行走相比,跑步机行走显示出相似的最佳 Cw,但速度更高。

更新日期:2021-04-13
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