Background. Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU). Aim. This study aims to better understand this new infection and report the changes in the various laboratory tests identified in critically ill patients and associated with poor prognosis among COVID-19 patients admitted to the ICU. Methods. This was a retrospective study that included 160 confirmed SARS-CoV-2-positive patients. Results. Elevated serum ferritin, D-dimer, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and nonconjugated bilirubin levels were present in 139 (96%), 131 (96%), 107 (68%), 52 (34%), and 89 (70%) patients, respectively. Renal parameters were abnormal in a significant number of cases with elevated creatinine and blood urea nitrogen in 93 (62%) and 102 (68%) cases, respectively. Hematological profiles revealed lower red blood cell count, hemoglobin, eosinophils, basophils, monocytes, and lymphocytes in 90 (57%), 103 (65%), 89 (62%), 105 (73%), 35 (24%), and 119 (83%) cases, respectively. The neutrophil count was found to increase in 71.3% of the cases. There was significantly higher mortality (83%) among patients older than 60 years and in female patients (75%) . Patients with lung diseases had a poor outcome compared to patients with other comorbidities . There was a significant association between elevated D-dimer levels and increased mortality . Elevated levels of AST, creatinine, blood urea nitrogen, and bilirubin were significantly associated with unfavorable outcomes. Conclusion. Different parameters can be used to predict disease prognosis, especially the risk of poor prognosis. Accurate diagnosis and monitoring of disease progression from the early stages will help in reducing mortality and unfavorable outcomes.

中文翻译：

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重症 COVID-19 患者预后不良的潜在预测因素：一项单中心研究

背景。及时发现高度传染性冠状病毒病 (COVID-19) 的进展对于重症监护 (ICU) 患者的管理和干预至关重要。瞄准。本研究旨在更好地了解这种新感染，并报告在重症患者中发现的各种实验室检查的变化，这些变化与入住 ICU 的 COVID-19 患者预后不良有关。方法。这是一项回顾性研究，包括 160 名确诊的 SARS-CoV-2 阳性患者。结果. 139 (96%)、131 (96%)、107 (68%)、52 (34%) 的血清铁蛋白、D-二聚体、天冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 和非结合胆红素水平升高, 和 89 (70%) 名患者, 分别。在肌酐和血尿素氮升高的病例中，肾脏参数异常分别为 93 例（62%）和 102 例（68%）。血液学特征显示，90 (57%)、103 (65%)、89 (62%)、105 (73%)、35 (24%) 的红细胞计数、血红蛋白、嗜酸性粒细胞、嗜碱性粒细胞、单核细胞和淋巴细胞较低，和 119 (83%) 例，分别。在 71.3% 的病例中发现中性粒细胞计数增加。60 岁以上患者的死亡率显着升高（83%）女性患者（75%）. 与其他合并症患者相比，肺部疾病患者的预后较差. D-二聚体水平升高与死亡率增加之间存在显着关联. AST、肌酐、血尿素氮和胆红素水平升高与不良结局显着相关。结论。不同的参数可用于预测疾病预后，尤其是预后不良的风险。从早期阶段准确诊断和监测疾病进展将有助于降低死亡率和不利结果。