Abstract

To assess the effect of silver nanoparticles on mice cognitive abilities, daily, up to 4-month period, experimental mice were administrated with silver nanoparticles solution. Accumulation of silver in brain was assessed by neutron activation analysis. Cognitive abilities in mice before and after silver nanoparticles administration were evaluated in the Morris water maze behavioral test. No significant differences in the amounts of silver accumulated in brain were found between capable and incapable animals. Silver accumulation in brain of experimental animals in 4-months experiment was higher than in 2-months experiment for both groups. In the main Morris water maze behavioral test at the control points of 2 and 4 months no statistically significant differences were found in the parameters of treks between experimental and control animals.

中文翻译：

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长期口服银纳米颗粒对小鼠认知能力的影响

摘要

为了评估银纳米颗粒对小鼠认知能力的影响，每天（长达4个月）向实验小鼠施用银纳米颗粒溶液。通过中子活化分析评估大脑中银的积累。在莫里斯水迷宫行为测试中评估了银纳米颗粒给药前后小鼠的认知能力。在有能力和无能力的动物之间，在大脑中积累的银量没有发现显着差异。两组的实验动物在4个月的实验中大脑中的银积累均高于2个月的实验。在主要莫里斯水迷宫行为测试中，在2和4个月的控制点上，实验动物和对照动物之间的跋涉参数没有统计学上的显着差异。