Journal of Industrial Textiles ( IF 3.2 ) Pub Date : 2021-04-12 , DOI: 10.1177/15280837211007508 Fabio Salvatore Palumbo 1 , Salvatore Federico 1 , Giovanna Pitarresi 1 , Calogero Fiorica 1 , Roberto Scaffaro 2 , Andrea Maio 2 , Emmanuel Fortunato Gulino 2 , Gaetano Giammona 1, 3
Electrospun nanofibers based on polysaccharides represent a consolidated approach in Tissue Engineering and Regenerative Medicine (TERM) and nanomedicine as a drug delivery system (DDS). In this work, two chemical derivatives of a low molecular weight gellan gum (96.7 kDa) with aliphatic pendant tails were processed by electrospinning technique into non-woven nanofibrous mats. In order to generate spinnable blends, it was necessary to associate poly vinyl alcohol (PVA). The relationships between the physicochemical properties and the processability via electrospinning technique of gellan gum alkyl derivatives (GG-C8 and GG-C12 having a degree of alkyl chain derivatization of 17 mol % and 18 mol %, respectively) were investigated. The deposition of nanometric fibers (212.4 nm ± 60.0) was achieved by using the blend GG-C8/PVA spinned at 5% w/v in water. The use of a binary solvent composed of water and ethanol in a volumetric ratio 95:5 improved further spinnability obtaining similar nanofiber diameters (218.0 nm ± 96.0). The rheological analysis has allowed to highlight the role of the alkyl portion (C8 and C12) on the spinnability of the blended polymers.
中文翻译:
结冷胶在电纺膜制备过程中烷基衍生作用的影响
基于多糖的静电纺丝纳米纤维代表了组织工程与再生医学(TERM)和作为药物递送系统(DDS)的纳米医学的综合方法。在这项工作中,通过静电纺丝技术将低分子量结冷胶(96.7 kDa)和脂肪族侧链的两种化学衍生物加工成非织造纳米纤维垫。为了产生可纺的共混物,必须结合聚乙烯醇(PVA)。吉兰糖胶烷基衍生物(GG-C 8和GG-C 12)的电纺技术的物理化学性质与可加工性之间的关系研究了具有分别为17mol%和18mol%的烷基链衍生化度的聚合物。通过使用在水中以5%w / v纺丝的GG-C 8 / PVA共混物,可以沉积纳米纤维(212.4 nm±60.0)。使用体积比为95:5的由水和乙醇组成的二元溶剂可进一步改善可纺性,从而获得相似的纳米纤维直径(218.0 nm±96.0)。流变学分析突出了烷基部分(C 8和C 12)对共混聚合物可纺性的作用。