Purpose

To report abnormal full-field electroretinograms (ERGs) in a patient with cystoid macular edema (CME) induced by systemic paclitaxel.

Methods

This is an observational case report. Full-field ERGs were recorded to evaluate the retinal function using the RETeval system and conventional ERGs using contact lens electrodes with built-in white light-emitting diodes. Optical coherence tomography (OCT) was also used to assess the retinal morphology.

Results

A 70-year-old man, who was diagnosed with gastric cancer, had undergone gastrectomy. Subsequently, systemic paclitaxel was administered once a week as an adjuvant therapy. After the tenth course of paclitaxel, he experienced blurred vision in both eyes and visited our department of ophthalmology. OCT revealed the presence of CME in both eyes, and the RETeval flicker ERGs showed a marked reduction in the amplitudes and a prolongation of the implicit times in both eyes. Conventional ERGs showed that the amplitudes of the oscillatory potentials (OPs) were also severely attenuated. The abnormal OCT findings and reduced visual acuity recovered to normal at 1 and 2 months, respectively, after the discontinuation of paclitaxel. However, the flicker ERGs did not recover to normal values until 4 months after the discontinuation of paclitaxel.

Conclusion

These results suggest that the ERGs can be used to monitor the changes in the overall retinal function in patients receiving paclitaxel.

中文翻译：

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紫杉醇全身给药引起黄斑囊样水肿的病例：视网膜电图评估

目的

报告全身性紫杉醇引起的黄斑囊样水肿 (CME) 患者的全视野视网膜电图 (ERG) 异常。

方法

这是一份观察性病例报告。记录全视野 ERG 以使用 RET评估系统和常规 ERG 使用带有内置白色发光二极管的隐形眼镜电极评估视网膜功能。光学相干断层扫描 (OCT) 也用于评估视网膜形态。

结果

一名 70 岁的男性被诊断出患有胃癌，接受了胃切除术。随后，每周一次全身性紫杉醇作为辅助治疗。服用紫杉醇第十疗程后，双眼视力模糊，就诊于我院眼科。OCT 显示双眼存在 CME，RET评估闪烁的 ERG 显示出双眼的振幅显着降低和隐性时间延长。传统的 ERG 显示振荡电位 (OP) 的幅度也严重衰减。停用紫杉醇后，OCT 异常和视力下降分别在 1 个月和 2 个月恢复正常。然而，直到停用紫杉醇 4 个月后，闪烁的 ERG 才恢复到正常值。

结论

这些结果表明 ERG 可用于监测接受紫杉醇治疗的患者整体视网膜功能的变化。