Objectives

To determine the intra-individual flow variation in serially acquired studies, and the influence of this variation on subsequent hemodynamic simulations using the inlet flow as a boundary condition. Author: Kindly check and confirm whether the corresponding authors are correctly identified.Confirmed.

Materials and methods

This prospective study included 51 patients (37 females and 14 males) with unruptured intracranial aneurysms who have received more than three times follow-up of 2D phase-contrast MR. The flow and velocity parameters were extracted to calculate the reproducibility and variation. Patient-specific computational fluid dynamics simulations were performed using the measured flows.

Results

Intraclass correlation coefficients for mean and maximum velocity and flow parameters ranged from 0.77 to 0.90. A 10% CV of mean flow was identified. Variations of 10% in inlet flow resulted in hemodynamic changes including 41.41% of peak systolic wall shear stress; 39.13% of end-diastolic wall shear stress; 2.79% of low shear area at peak systole; 2.12% of low shear area at end diastole: 47.57% of time-averaged wall shear stress; and 0.17% of oscillatory shear index.

Conclusion

This study identified 10% of intra-individual mean flow variation on phase-contrast MR. Intra-individual flow variation resulted in a non-negligible variation in wall shear stress, but relatively small variation in low shear area in hemodynamic calculations.

中文翻译：

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通过 MRI 识别颅内动脉血流的个体内变异及其对计算的血流动力学描述符的影响

目标

确定连续获得的研究中的个体内流量变化，以及这种变化对使用入口流量作为边界条件的后续血流动力学模拟的影响。作者：请检查并确认通讯作者是否正确识别。确认。

材料和方法

这项前瞻性研究包括 51 名未破裂颅内动脉瘤患者（37 名女性和 14 名男性），他们接受了 2D 相位对比 MR 的 3 次以上随访。提取流量和速度参数以计算再现性和变化。使用测量的流量进行患者特定的计算流体动力学模拟。

结果

平均和最大速度和流量参数的组内相关系数范围为 0.77 至 0.90。确定了 10% CV 的平均流量。入口流量 10% 的变化导致血流动力学变化，包括 41.41% 的峰值收缩期壁剪切应力；39.13% 的舒张末期壁剪应力；收缩峰时 2.79% 的低剪切面积；舒张末期低剪切面积的 2.12%：时间平均壁剪应力的 47.57%；和 0.17% 的振荡剪切指数。

结论

这项研究确定了 10% 的个体内平均流量变化对相衬 MR。个体内部的流动变化导致壁剪切应力的变化不可忽略，但在血流动力学计算中低剪切面积的变化相对较小。