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Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods
Science ( IF 56.9 ) Pub Date : 2021-04-09 , DOI: 10.1126/science.abe7790
Robin J Vigouroux 1 , Karine Duroure 1 , Juliette Vougny 2 , Shahad Albadri 1 , Peter Kozulin 3 , Eloisa Herrera 4 , Kim Nguyen-Ba-Charvet 1 , Ingo Braasch 5 , Rodrigo Suárez 3 , Filippo Del Bene 1 , Alain Chédotal 1
Affiliation  

In most vertebrates, camera-style eyes contain retinal ganglion cell neurons that project to visual centers on both sides of the brain. However, in fish, ganglion cells were thought to innervate only the contralateral side, suggesting that bilateral visual projections appeared in tetrapods. Here we show that bilateral visual projections exist in non-teleost fishes and that the appearance of ipsilateral projections does not correlate with terrestrial transition or predatory behavior. We also report that the developmental program that specifies visual system laterality differs between fishes and mammals, as the Zic2 transcription factor, which specifies ipsilateral retinal ganglion cells in tetrapods, appears to be absent from fish ganglion cells. However, overexpression of human ZIC2 induces ipsilateral visual projections in zebrafish. Therefore, the existence of bilateral visual projections likely preceded the emergence of binocular vision in tetrapods.



中文翻译:

双边视觉投射存在于非硬骨鱼中,早于四足动物的出现

在大多数脊椎动物中,照相机式的眼睛包含投射到大脑两侧视觉中心的视网膜神经节细胞神经元。然而,在鱼类中,神经节细胞被认为仅支配对侧,这表明双侧视觉投影出现在四足动物中。在这里,我们表明在非硬骨鱼类中存在双边视觉投影,并且同侧投影的出现与陆地过渡或捕食行为无关。我们还报告说,指定视觉系统偏侧性的发育程序在鱼类和哺乳动物之间有所不同,因为在四足动物中指定同侧视网膜神经节细胞的 Zic2 转录因子似乎在鱼神经节细胞中不存在。然而,人类 ZIC2 的过表达会在斑马鱼中诱导同侧视觉投射。所以,

更新日期:2021-04-09
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