当前位置: X-MOL 学术Neurophotonics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Evaluating a new generation of wearable high-density diffuse optical tomography technology via retinotopic mapping of the adult visual cortex
Neurophotonics ( IF 5.3 ) Pub Date : 2021-04-01 , DOI: 10.1117/1.nph.8.2.025002
Ernesto E. Vidal-Rosas 1 , Hubin Zhao 1 , Reuben W. Nixon-Hill 2 , Greg Smith 3 , Luke Dunne 3 , Samuel Powell 3 , Robert J. Cooper 1 , Nicholas L. Everdell 1
Affiliation  

Significance: High-density diffuse optical tomography (HD-DOT) has been shown to approach the resolution and localization accuracy of blood oxygen level dependent-functional magnetic resonance imaging in the adult brain by exploiting densely spaced, overlapping samples of the probed tissue volume, but the technique has to date required large and cumbersome optical fiber arrays. Aim: To evaluate a wearable HD-DOT system that provides a comparable sampling density to large, fiber-based HD-DOT systems, but with vastly improved ergonomics. Approach: We investigated the performance of this system by replicating a series of classic visual stimulation paradigms, carried out in one highly sampled participant during 15 sessions to assess imaging performance and repeatability. Results: Hemodynamic response functions and cortical activation maps replicate the results obtained with larger fiber-based systems. Our results demonstrate focal activations in both oxyhemoglobin and deoxyhemoglobin with a high degree of repeatability observed across all sessions. A comparison with a simulated low-density array explicitly demonstrates the improvements in spatial localization, resolution, repeatability, and image contrast that can be obtained with this high-density technology. Conclusions: The system offers the possibility for minimally constrained, spatially resolved functional imaging of the human brain in almost any environment and holds particular promise in enabling neuroscience applications outside of the laboratory setting. It also opens up new opportunities to investigate populations unsuited to traditional imaging technologies.

中文翻译:

通过成人视皮层的视网膜定位成像评估新一代可穿戴高密度漫射光学层析成像技术

意义:高密度漫射光学层析成像(HD-DOT)已被证明可以通过利用密集的,重叠的探测组织体积样本来达到成人大脑中血氧水平依赖性功能磁共振成像的分辨率和定位精度,但是迄今为止,该技术仍需要大型且麻烦的光纤阵列。目的:评估一种可穿戴的HD-DOT系统,该系统可提供与大型基于光纤的HD-DOT系统相当的采样密度,但其人体工程学得到了极大的改善。方法:我们通过复制一系列经典的视觉刺激范例来研究该系统的性能,该范例在15个疗程中的一个高采样参与者中进行,以评估成像性能和可重复性。结果:血流动力学响应函数和皮层激活图可复制使用较大的基于纤维的系统获得的结果。我们的结果表明,在氧合血红蛋白和脱氧血红蛋白中均具有局部活化作用,在所有疗程中均观察到高度重复性。与模拟的低密度阵列的比较清楚地表明了可以通过这种高密度技术获得的空间定位,分辨率,可重复性和图像对比度方面的改进。结论:该系统提供了在几乎任何环境下对人脑进行最小约束,空间分辨的功能成像的可能性,并且在实现实验室以外的神经科学应用方面具有特殊的前景。它还为调查不适合传统成像技术的人群提供了新的机会。
更新日期:2021-04-09
down
wechat
bug