Bacterial infection is a highly complex biological process involving a dynamic interaction between the invading microorganism and the host. Specifically, intracellular pathogens seize control over the host cellular processes including membrane dynamics, actin cytoskeleton, phosphoinositide metabolism, intracellular trafficking and immune defense mechanisms to promote their host colonization. To accomplish such challenging tasks, virulent bacteria deploy unique species-specific secreted effectors to evade and/or subvert cellular defense surveillance mechanisms to establish a replication niche. However, despite superficially similar infection strategies, diverse Rickettsia species utilize different effector repertoires to promote host colonization. This review will discuss our current understandings on how different Rickettsia species deploy their effector arsenal to manipulate host cellular processes to promote their intracytosolic life within the mammalian host.

中文翻译：

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立克次体-宿主相互作用：胞质内宿主定植策略

细菌感染是一个高度复杂的生物过程，涉及入侵微生物与宿主之间的动态相互作用。具体来说，细胞内病原体控制宿主细胞过程，包括膜动力学、肌动蛋白细胞骨架、磷酸肌醇代谢、细胞内运输和免疫防御机制，以促进其宿主定植。为了完成此类具有挑战性的任务，有毒细菌会部署独特的物种特异性分泌效应器来逃避和/或破坏细胞防御监视机制以建立复制生态位。然而，尽管表面上相似的感染策略，不同的立克次体物种利用不同的效应子库来促进宿主定植。这篇综述将讨论我们目前对不同立克次体物种如何部署其效应器库来操纵宿主细胞过程以促进其在哺乳动物宿主内的胞质内生活的理解。