Rationale

Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in different plants and vegetables like soybeans that share a common chemical structure. Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities.

Objectives

Based on these previous studies, we investigated the effects of three natural isoflavones, daidzin, daidzein, and genistein, on the modulation of the cocaine reinforcing effects and on cue-induced reinstatement in an operant mouse model of cocaine self-administration.

Results

Chronic treatment with daidzein or genistein decreased operant responding to obtain cocaine intravenous infusions. On the other hand, daidzein and daidzin, but not genistein, were effective in decreasing cue-induced cocaine reinstatement. Complementary studies revealed that daidzein effects on cocaine reinforcement were mediated through a mechanism that involved dopamine type-2/3 receptors (DA-D2/3) activities.

Conclusions

Our results suggest that these natural compounds alone or in combination can be a potential therapeutic approach for cocaine addiction. Further clinical studies are required in order to ascertain their potential therapeutic use.

中文翻译：

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大豆苷元调节CD-1雄性小鼠的可卡因增强作用和提示诱导的可卡因恢复

基本原理

可卡因成瘾是一种慢性复发性疾病，缺乏有效的治疗方法。异黄酮是存在于不同植物和蔬菜（如大豆）中的一组化合物，它们具有共同的化学结构。先前的研究已经描述了天然异黄酮黄豆苷的合成衍生物可以通过涉及醛脱氢酶（ALDH）活性的机制来调节可卡因成瘾。

目标

基于这些先前的研究，我们调查了可卡因自我管理的可操作小鼠模型中三种天然异黄酮，大豆苷元，大豆苷元和染料木黄酮对可卡因增强作用的调节和提示诱导的恢复作用。

结果

大豆苷元或染料木黄酮的长期治疗降低了获得可卡因静脉滴注的手术反应。另一方面，黄豆苷元和黄豆苷元，但不是染料木黄酮，可以有效减少提示诱导的可卡因恢复。补充研究表明，大豆苷元对可卡因强化的作用是通过一种涉及多巴胺2/3型受体（DA-D2 / 3）活性的机制介导的。

结论

我们的结果表明，这些天然化合物单独或组合使用可成为可卡因成瘾的潜在治疗方法。为了确定其潜在的治疗用途，需要进一步的临床研究。