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Association between pyrethroid exposure and cardiovascular disease: A national population-based cross-sectional study in the US
Environment International ( IF 11.8 ) Pub Date : 2021-04-09 , DOI: 10.1016/j.envint.2021.106545
Qingping Xue 1 , An Pan 2 , Ying Wen 3 , Yichao Huang 4 , Da Chen 4 , Chun-Xia Yang 5 , Jason Hy Wu 6 , Jie Yang 7 , Jay Pan 8 , Xiong-Fei Pan 9
Affiliation  

Objective

Pyrethroids-containing products are widely used as commercial and household insecticides. While animal studies and clinical case reports have shown acute cardiovascular outcomes of pyrethroids exposure, little has been known on the effect of chronic pyrethroid exposure on cardiovascular disease (CVD). We aimed to examine the associations between chronic pyrethroid exposure and CVD in the US adults.

Methods

Cross-sectional data from the National Health and Nutrition Examination Survey 1999–2002 and 2007–2012 were analyzed. The exposure to pyrethroids was determined as the urinary level of 3-phenoxybenzoic acid (3-PBA), and CVD was ascertained based on self-reported physician diagnoses. Multivariable logistic regression models were fitted to evaluate associations of pyrethroid exposure with CVD, coronary heart disease (CHD), and stroke.

Results

Included were 6,471 participants with a mean age of 44.77 years (standard error, 0.39) for final analyses. The weighted prevalence of CVD, CHD, and stroke was 6.85%, 4.57% and 2.27%, respectively. With adjustments for major confounders, participants in the highest tertile of urinary 3-PBA had higher odds of CVD (odds ratio, 1.58; 95% confidence interval: 1.12, 2.23) and CHD (OR, 1.75; 95% CI: 1.17, 2.61) compared to those in the lowest tertile. There were linear associations for CVD (P for trend = 0.04) and CHD (P for trend = 0.02). However, no significant association was noted for stroke (1.29; 0.78, 2.16) in the main analyses.

Conclusions

3-PBA was adversely associated with CVD and CHD in the US adults. Our findings highlight potential cardiovascular risk of chronic exposure to pyrethroids, and should be validated in large prospective studies in different populations in future.



中文翻译:

拟除虫菊酯暴露与心血管疾病之间的关联:美国一项基于全国人口的横断面研究

客观的

含拟除虫菊酯的产品被广泛用作商业和家用杀虫剂。尽管动物研究和临床病例报告显示了拟除虫菊酯暴露的急性心血管结局,但对于长期暴露于拟除虫菊酯对心血管疾病(CVD)的影响知之甚少。我们旨在检查美国成年人中慢性拟除虫菊酯暴露与CVD之间的关联。

方法

分析了1999-2002年和2007-2012年美国国家健康和营养检查调查的横断面数据。拟除虫菊酯的暴露确定为3-苯氧基苯甲酸(3-PBA)的尿水平,并根据自我报告的医生诊断确定CVD。拟合多变量逻辑回归模型以评估拟除虫菊酯暴露与CVD,冠心病(CHD)和中风的相关性。

结果

其中包括6,471名参与者,其平均年龄为44.77岁(标准误差为0.39)以进行最终分析。CVD,CHD和中风的加权患病率分别为6.85%,4.57%和2.27%。在对主要混杂因素进行调整后,尿液3-PBA最高三分位数的参与者发生CVD的几率较高(优势比为1.58; 95%置信区间:1.12、2.23)和冠心病(OR为1.75; 95%CI:1.17、2.61) )与最低三分位数中的相比)。CVD(趋势的P = 0.04)和CHD(趋势的P = 0.02)存在线性关联。然而,在主要分析中,并未发现卒中的显着相关性(1.29; 0.78,2.16)。

结论

在美国成年人中,3-PBA与CVD和CHD呈不利关系。我们的发现凸显了长期暴露于拟除虫菊酯的潜在心血管风险,并应在未来针对不同人群的大规模前瞻性研究中进行验证。

更新日期:2021-04-09
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