Meniscal injuries are common and often induce knee pain requiring surgical intervention. To develop effective strategies for meniscus regeneration, we hypothesized that a minced meniscus embedded in an atelocollagen gel, a firm gel-like material, may enhance meniscus regeneration through cell migration and proliferation in the gel. Hence, the objective of this study was to investigate cell migration and proliferation in atelocollagen gels seeded with autologous meniscus fragments in vitro and examine the therapeutic potential of this combination in an in vivo rabbit model of massive meniscus defect.

中文翻译：

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嵌入胶原蛋白凝胶中的自体半月板碎片可增强兔子模型中的半月板修复。

半月板损伤很常见，通常会导致膝盖疼痛，需要进行手术干预。为了制定半月板再生的有效策略，我们假设嵌在atelcollagen凝胶（一种牢固的凝胶状材料）中的切碎的半月板可以通过细胞迁移和在凝胶中增殖来增强半月板再生。因此，本研究的目的是在体外接种自体半月板碎片的端粒胶原蛋白凝胶中研究细胞迁移和增殖，并检查该组合在大面积半月板缺损的体内兔模型中的治疗潜力。