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Novel Dicistroviruses in an Unexpected Wide Range of Invertebrates
Food and Environmental Virology ( IF 3.4 ) Pub Date : 2021-04-10 , DOI: 10.1007/s12560-021-09472-2
Ruo-Lin Cheng 1 , Xiao-Feng Li 1 , Chuan-Xi Zhang 2
Affiliation  

Dicistroviruses are members of a rapidly growing family of small RNA viruses. Related sequences have been discovered in many environmental samples, indicating that our knowledge about dicistrovirus diversity and host range is still limited. In this study, we performed a systematic search against the publicly available transcriptome database, and identified large numbers of dicistrovirus-like sequences in a wide variety of eukaryotic species. The origins of these sequences were 108 invertebrates (including 77 insect species belonging to 18 orders) and 11 plants, revealing new associations between dicistroviruses and hosts. Finally, 83 transcripts corresponding to nearly-complete viral genomes were retrieved from the RNA-seq data, of which most sequences showed limited similarity to known dicistroviruses and might present previously unreported virus species. Phylogenetic analysis suggested that horizontal virus transfer has occurred between diverse hosts and has important implications for dicistrovirus evolution. The results will provide new insight into the hidden diversity of the Dicistroviridae, and help us to better understand the viral evolution, host range and the possible way of transmission.



中文翻译:

出乎意料的广泛无脊椎动物中的新型双顺式病毒

双顺反病毒是快速增长的小 RNA 病毒家族的成员。在许多环境样本中发现了相关序列,表明我们对双顺反病毒多样性和宿主范围的了解仍然有限。在这项研究中,我们对公开可用的转录组数据库进行了系统搜索,并在多种真核物种中鉴定了大量的双顺反病毒样序列。这些序列的起源是 108 种无脊椎动物(包括 77 种昆虫,属于 18 目)和 11 种植物,揭示了双顺反病毒与宿主之间的新关联。最后,从 RNA-seq 数据中检索到与几乎完整的病毒基因组相对应的 83 个转录本,其中大多数序列与已知的双顺反病毒显示出有限的相似性,并且可能存在以前未报道的病毒种类。系统发育分析表明,不同宿主之间发生了水平病毒转移,对双顺反病毒进化具有重要意义。研究结果将提供对隐藏的多样性的新见解Dicistroviridae,并帮助我们更好地了解病毒的进化、宿主范围和可能的传播方式。

更新日期:2021-04-11
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