The study aimed to implement realistic source models of a computed tomography (CT) scanner and Monte Carlo simulations to actual patient data and to calculate patient-specific organ and effective dose estimates for patients undergoing dynamic CT myocardial perfusion examinations. Source models including bowtie filter, tube output and x-ray spectra were determined for a dual-source Siemens Somatom Definition Flash scanner. Twenty CT angiography patient datasets were merged with a scaled International Commission on Radiological Protection (ICRP) 110 voxel phantom. Dose simulations were conducted with ImpactMC software. Effective dose estimates varied from 5.0 to 14.6 mSv for the 80 kV spectrum and from 8.9 to 24.7 mSv for the 100 kV spectrum. Significant differences in organ doses and effective doses between patients emphasise the need to use actual patient data merged with matched anthropomorphic anatomy in the dose simulations to achieve a reasonable level of accuracy in the dose estimation procedure.

中文翻译：

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动态计算机断层扫描心肌灌注检查中患者特定剂量估计

该研究旨在对实际患者数据实施计算机断层扫描 (CT) 扫描仪的真实源模型和蒙特卡罗模拟，并为接受动态 CT 心肌灌注检查的患者计算患者特定器官和有效剂量估计。源模型（包括领结滤波器、管输出和 X 射线光谱）是针对双源西门子 Somatom Definition Flash 扫描仪确定的。将 20 个 CT 血管造影患者数据集与按比例缩放的国际放射防护委员会 (ICRP) 110 体素模型合并。使用 ImpactMC 软件进行剂量模拟。80 kV 频谱的有效剂量估计值从 5.0 到 14.6 mSv，100 kV 频谱的有效剂量估计值从 8.9 到 24.7 mSv。患者之间器官剂量和有效剂量的显着差异强调需要在剂量模拟中使用与匹配的拟人解剖结构合并的实际患者数据，以在剂量估计过程中达到合理的准确度。