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Permeation of polyethylene glycols across the tympanic membrane
Giant Pub Date : 2021-04-08 , DOI: 10.1016/j.giant.2021.100057
Wei Zhang 1 , Brendan Harty 1 , Yueqin Zheng 1 , Zipei Zhang 1 , Xiyu Li 1 , Dali Wang 1 , Daniel S Kohane 1
Affiliation  

Localized and non-invasive delivery of therapeutics across barriers in the body is challenging. Examples include the flux of drugs across the tympanic membrane (TM) for the treatment of middle ear infections, and across the round window to treat inner ear disease. With the emergence of macromolecular therapies, the question arises as to whether such delivery can be achieved with macromolecules. Here, we have used polyethylene glycols (PEGs) in solutions to investigate macromolecular permeation across the TM in the chinchilla ex vivo. As the molecular weight of PEG increased, flux across the TM decreased, with an exponential relationship between the apparent diffusion coefficient and the molecular weight of the polymers. PEG flux was further decreased if it was released from a poloxamer 407 hydrogel, and lessened with increasing hydrogel concentration. Our results provide a framework for understanding the permeation of macromolecules noninvasively across barriers.



中文翻译:

聚乙二醇通过鼓膜的渗透

跨越体内屏障的局部和非侵入性治疗方法具有挑战性。例子包括药物穿过鼓膜 (TM) 以治疗中耳感染,以及穿过圆窗以治疗内耳疾病。随着大分子疗法的出现,问题在于是否可以用大分子实现这种递送。在这里,我们在溶液中使用聚乙二醇 (PEG) 来研究大分子在体外龙猫中跨 TM 的渗透. 随着 PEG 分子量的增加,穿过 TM 的通量降低,表观扩散系数与聚合物的分子量之间呈指数关系。如果它从泊洛沙姆 407 水凝胶中释放出来,PEG 通量会进一步降低,并且随着水凝胶浓度的增加而减少。我们的研究结果为理解大分子无创跨越障碍的渗透提供了一个框架。

更新日期:2021-04-18
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