Cutaneous and renal glomerular vasculopathy (CRGV) is an emerging disease in the UK, but its aetiology remains unclear. It is considered a thrombotic microangiopathy (TMA) in which the kidney and skin are the most commonly affected organs. We now document two cases of CRGV with brain lesions, which may have accounted for neurological signs displayed by these animals. The histopathological brain lesions were similar to TMA lesions in humans with thrombotic thrombocytopaenic purpura (TTP) and complement-mediated haemolytic uraemic syndrome (CM-HUS), in which the neurological signs are more associated with TMA than with any systemic disease or electrolyte imbalance. Fibrinoid necrosis in brain arterioles and associated lesions in these dogs were similar to those in human CM-HUS, indicating that the alternative complement pathway may play an important role in the pathophysiology of CRGV.

皮肤和肾脏肾小球血管病 (CRGV) 是英国的一种新兴疾病，但其病因尚不清楚。它被认为是一种血栓性微血管病 (TMA)，其中肾脏和皮肤是最常受影响的器官。我们现在记录了两个具有脑损伤的 CRGV 病例，这可能解释了这些动物表现出的神经系统症状。组织病理学脑部病变与患有血栓性血小板减少性紫癜 (TTP) 和补体介导的溶血性尿毒症综合征 (CM-HUS) 的人类 TMA 病变相似，其中神经系统体征与 TMA 的相关性高于任何全身性疾病或电解质失衡。这些狗的脑小动脉中的纤维蛋白样坏死和相关病变与人类 CM-HUS 中的相似，