Elevated visceral adipose tissue (VAT) has been associated with cardiometabolic risk factors including chronic systemic low-grade inflammation. Whereas the cognitive implications of inflammation have been extensively studied in preclinical models, the influence of inflammatory cytokines on cognitive function in humans is unclear. This study aimed to investigate the relations among VAT, inflammatory cytokines, and cognitive control. We hypothesized that inflammatory markers would mediate the negative influence of VAT on selective attention. Participants between 25 and 46 years (N = 115, 43 females) underwent a DXA scan to estimate VAT. A modified Eriksen Flanker task was used to assess attentional inhibitory control while event-related potentials were recorded. ELISA was used to quantify plasma C-reactive protein (CRP) and Interleukin-6 (IL-6) concentrations. Mediation modeling while controlling for diet quality and education level revealed that CRP concentrations significantly mediated the relationship between VAT and incongruent trial accuracy (indirect effect 95% CI {−0.24, −0.01}). Further, IL-6 concentrations had a significant mediation effect on the relationship between VAT and incongruent P3 peak latency (indirect effect 95% CI {0.05, 1.39}). These results suggest that mechanisms by which visceral adiposity exerts a negative influence on cognitive function includes systemic inflammation.

升高的内脏脂肪组织 (VAT) 与心脏代谢危险因素有关，包括慢性全身性低度炎症。虽然炎症对认知的影响已在临床前模型中得到广泛研究，但炎症细胞因子对人类认知功能的影响尚不清楚。本研究旨在探讨增值税、炎性细胞因子和认知控制之间的关系。我们假设炎症标志物会介导增值税对选择性注意的负面影响。25 至 46 岁的参与者（N = 115，43 名女性）接受了 DXA 扫描以估算增值税。修改后的 Eriksen Flanker 任务用于评估注意力抑制控制，同时记录事件相关电位。ELISA 用于量化血浆 C 反应蛋白 (CRP) 和白细胞介素 6 (IL-6) 浓度。控制饮食质量和教育水平的中介模型显示，CRP 浓度显着调节了增值税与不一致试验准确性之间的关系（间接影响 95% CI {-0.24, -0.01}）。此外，IL-6 浓度对 VAT 与不一致的 P3 峰值潜伏期之间的关系具有显着的中介作用（间接影响 95% CI {0.05, 1.39}）。这些结果表明，内脏肥胖对认知功能产生负面影响的机制包括全身炎症。控制饮食质量和教育水平的中介模型显示，CRP 浓度显着调节了增值税与不一致试验准确性之间的关系（间接影响 95% CI {-0.24, -0.01}）。此外，IL-6 浓度对 VAT 与不一致的 P3 峰值潜伏期之间的关系具有显着的中介作用（间接影响 95% CI {0.05, 1.39}）。这些结果表明，内脏肥胖对认知功能产生负面影响的机制包括全身炎症。控制饮食质量和教育水平的中介模型显示，CRP 浓度显着调节了增值税与不一致试验准确性之间的关系（间接影响 95% CI {-0.24, -0.01}）。此外，IL-6 浓度对 VAT 与不一致的 P3 峰值潜伏期之间的关系具有显着的中介作用（间接影响 95% CI {0.05, 1.39}）。这些结果表明，内脏肥胖对认知功能产生负面影响的机制包括全身炎症。