Schizophrenia (SZ), bipolar disorder (BD) and major depression disorder (MDD) have been regarded as highly diverged independent entities in current psychiatric diagnosis. However, ample new evidence suggests that they may have common biological traits. Neuroimaging studies showed that psychiatric disorders might associated with altered grey matter (GM) asymmetry compared to controls; however, the degree to which SZ, BD and MDD have common and/or distinct asymmetrical alterations in GM is still ambiguous. In this study, we analysed 169 voxel-based studies (including 3517 SZ patients, 1575 BD patients, 3280 MDD patients and 9733 controls) using activation likelihood estimation (ALE) meta-analysis to systematically review the existence of similar GM atrophy and asymmetrical alteration patterns among these psychiatric disorders, and the functional association between behaviour domains and topological alterations. We found that the right parahippocampal gyrus and left superior frontal gyrus showed commonly altered GM volume across all three illnesses, but did not identify common asymmetrical alteration. The asymmetrical alteration with leftward bias appeared in SZ and bipolar disorder at different locations, but more asymmetrical alteration with rightward bias appeared in MDD. Moreover, these changes have been confirmed to be associate with several symptoms and may have roles in functional networks. Our findings support the existence of common neurobiological damnification in these psychiatric disorders and provides valuable insights for the neural commonalties among different psychiatric disorders based on a large sample size.

精神分裂症 (SZ)、双相情感障碍 (BD) 和重度抑郁症 (MDD) 在当前的精神病学诊断中被认为是高度分化的独立实体。然而，大量新证据表明它们可能具有共同的生物学特征。神经影像学研究表明，与对照组相比，精神疾病可能与改变的灰质 (GM) 不对称有关；然而，SZ、BD 和 MDD 在 GM 中具有共同和/或明显的不对称改变的程度仍然模棱两可。在这项研究中，我们使用激活似然估计 (ALE) 荟萃分析分析了 169 项基于体素的研究（包括 3517 名 SZ 患者、1575 名 BD 患者、3280 名 MDD 患者和 9733 名对照），以系统评价类似 GM 萎缩和不对称改变的存在这些精神疾病的模式，以及行为域和拓扑变化之间的功能关联。我们发现右侧海马旁回和左侧额上回在所有三种疾病中都表现出常见的 GM 体积改变，但没有发现常见的不对称改变。SZ和双相障碍在不同部位均出现左偏不对称性改变，而MDD则更多地出现右偏不对称性改变。此外，这些变化已被证实与多种症状相关，并可能在功能网络中发挥作用。我们的研究结果支持在这些精神疾病中存在常见的神经生物学诅咒，并基于大样本量为不同精神疾病之间的神经共性提供有价值的见解。