Human parechovirus (HPeV) is one of the members of the family Picornaviridae that has been associated with fever of unknown origin, gastroenteritis, clinical sepsis, meningitis, or encephalitis in very young infants. HPeV detection is not routinely performed in most clinical microbiology laboratories in Argentina and, therefore, its real prevalence is unknown. We here report three cases of HPeV CNS infection that presented to our hospital with different clinical features after the implementation of a multiplex PCR meningitis/encephalitis panel. Molecular diagnostic techniques could help improve patient care and understand the real prevalence of this infection in Argentina.

人类副胆囊病毒 (HPeV) 是小核糖核酸病毒科的成员之一，与非常年幼婴儿的不明原因发热、肠胃炎、临床败血症、脑膜炎或脑炎有关。HPeV 检测并未在阿根廷的大多数临床微生物实验室常规进行，因此其实际流行率尚不清楚。我们在此报告了三例 HPeV 中枢神经系统感染病例，这些病例在实施多重 PCR 脑膜炎/脑炎小组后呈现给我们医院，具有不同的临床特征。分子诊断技术可以帮助改善患者护理并了解这种感染在阿根廷的实际流行情况。