Background: Gestational diabetes mellitus (GDM) is a major macrosomia risk factor. Variations in the catechol-O-methyltransferase (COMT; rs4680) genotypes are associated with heightened susceptibility to environmental exposures and nutritional conditions. However, macrosomia risks associated with COMT genetics, epigenetics, and the interaction between genetic and epigenetics among children with and without exposure to GDM are unknown.

中文翻译：

---

与儿茶酚-O-甲基转移酶基因型和遗传-表观遗传相互作用相关的巨大儿风险在有和没有妊娠期糖尿病暴露的儿童中

背景：妊娠期糖尿病（GDM）是巨大儿的主要危险因素。儿茶酚-O-甲基转移酶（COMT；rs4680）基因型的变异与对环境暴露和营养条件的敏感性增加有关。然而，与 COMT 遗传学、表观遗传学以及暴露或未暴露于 GDM 的儿童的遗传与表观遗传学之间的相互作用相关的巨大儿风险尚不清楚。