Individuals with primary progressive aphasia (PPA) exhibit differential impairment patterns in noun and verb naming, but it remains unclear whether anomia treatment results in similar improvements in noun and verb naming. Therefore, we examined the immediate and long-term (3-months post-treatment) behavioral and neural effects of an anomia treatment on object and action naming skills in PPA. A case-series design was utilized involving two individuals with PPA. Object and action words were trained concurrently and probed regularly using word lists matched on a number of lexical characteristics. One participant showed improvements in all word categories with different effect sizes whereas the other participant demonstrated improved naming only on trained object words. Treatment-induced fMRI changes were found in both hemispheres, with distinct patterns observed across participants. Further research is needed to better understand the effects of residual language and cognitive skills on behavioral and neurophysiological outcomes following anomia treatment for PPA.

患有原发性进行性失语症 (PPA) 的个体在名词和动词命名方面表现出不同的损伤模式，但目前尚不清楚失语症治疗是否会导致名词和动词命名的类似改善。因此，我们检查了失常治疗对 PPA 对象和动作命名技能的即时和长期（治疗后 3 个月）行为和神经影响。使用案例系列设计，涉及两个 PPA 个体。同时训练对象词和动作词，并使用在许多词汇特征上匹配的词表定期探索。一名参与者在具有不同效果大小的所有单词类别中表现出改进，而另一名参与者仅在受过训练的对象词上表现出改进的命名。在两个半球都发现了治疗引起的 fMRI 变化，在参与者中观察到不同的模式。需要进一步研究以更好地了解残余语言和认知技能对 PPA 异常治疗后行为和神经生理学结果的影响。