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Myelin water fraction decrease in individuals with chronic mild traumatic brain injury and persistent symptoms
Heliyon ( IF 4 ) Pub Date : 2021-04-06 , DOI: 10.1016/j.heliyon.2021.e06709
Bretta Russell-Schulz 1 , Irene M Vavasour 1 , Jing Zhang 2 , Alex L MacKay 1, 3 , Victoria Purcell 4 , Angela M Muller 5 , Leyla R Brucar 5 , Ivan J Torres 4, 6 , William J Panenka 2, 4 , Naznin Virji-Babul 5, 7
Affiliation  

The diffuse and continually evolving secondary changes after mild traumatic brain injury (mTBI) make it challenging to assess alterations in brain-behaviour relationships. In this study we used myelin water imaging to evaluate changes in myelin water fraction (MWF) in individuals with chronic mTBI and persistent symptoms and measured their cognitive status using the NIH Toolbox Cognitive Battery. Fifteen adults with mTBI with persistent symptoms and twelve age, gender and education matched healthy controls took part in this study. We found a significant decrease in global white matter MWF in patients compared to the healthy controls. Significantly lower MWF was evident in most white matter region of interest (ROIs) examined including the corpus callosum (separated into genu, body and splenium), minor forceps, right anterior thalamic radiation, left inferior longitudinal fasciculus; and right and left superior longitudinal fasciculus and corticospinal tract. Although patients showed lower cognitive functioning, no significant correlations were found between MWF and cognitive measures. These results suggest that individuals with chronic mTBI who have persistent symptoms have reduced MWF.



中文翻译:

患有慢性轻度创伤性脑损伤和持续症状的个体的髓磷脂水分数降低

轻度创伤性脑损伤(mTBI)后弥漫性且持续演变的继发性变化使得评估大脑行为关系的改变具有挑战性。在这项研究中,我们使用髓磷脂水成像来评估患有慢性 mTBI 和持续症状的个体髓磷脂水分数 (MWF) 的变化,并使用 NIH Toolbox Cognitive Battery 测量他们的认知状态。15 名患有持续症状的 mTBI 成年人和 12 名年龄、性别和教育程度与健康对照相匹配的健康对照者参加了这项研究。我们发现与健康对照相比,患者的全球白质 MWF 显着下降。在检查的大多数白质感兴趣区域 (ROI) 中,MWF 明显较低,包括胼胝体(分为膝部、体部和压部)、小镊子、右前丘脑辐射、左下纵束;以及左右上纵束和皮质脊髓束。尽管患者的认知功能较低,但未发现 MWF 与认知测量之间存在显着相关性。这些结果表明,患有持续性症状的慢性 mTBI 患者的 MWF 有所减少。

更新日期:2021-04-08
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