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Epigenetic regulation of mRNA N6-methyladenosine modifications in mammalian gametogenesis
Molecular Human Reproduction ( IF 4 ) Pub Date : 2021-04-05 , DOI: 10.1093/molehr/gaab025
Fang Fang 1 , Xiao Wang 2 , Zili Li 3 , Ke Ni 4 , Chengliang Xiong 3, 5
Affiliation  

N6-methyladenosine (m6A) is the most prevalent epigenetic modification of mRNAs and broadly influences various biological processes by regulating post-transcriptional gene expression in eukaryotes. The reversible m6A modification is catalyzed by methyltransferases, METTL3 and METTL14 (writers), removed by the demethylases FTO and ALKBH5 (erasers) and recognized by m6A-binding proteins, namely the YTH domain-containing family of proteins (readers). Both m6A modification and the related enzymes are involved in the regulation of normal gametogenesis and embryonic development in many species. Recent studies showed that loss of m6A compromises gamete maturation, sex hormone synthesis, fertility and early embryonic development. In this review, we have summarized the most recent findings on the role of mRNA m6A modification in mammalian gametogenesis to emphasize the epigenetic regulation of mRNA in the reproductive system.

中文翻译:

哺乳动物配子发生中 mRNA N6-甲基腺苷修饰的表观遗传调控

N6-甲基腺苷 (m6A) 是最普遍的 mRNA 表观遗传修饰,通过调节真核生物中的转录后基因表达广泛影响各种​​生物学过程。可逆的 m6A 修饰由甲基转移酶 METTL3 和 METTL14(写入器)催化,被去甲基化酶 FTO 和 ALKBH5(擦除器)去除并被 m6A 结合蛋白识别,即包含 YTH 结构域的蛋白质家族(读取器)。m6A 修饰和相关酶都参与了许多物种正常配子发生和胚胎发育的调节。最近的研究表明,m6A 的缺失会影响配子成熟、性激素合成、生育能力和早期胚胎发育。在本次审查中,
更新日期:2021-04-05
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