Sickle cell disease (SCD) as other chronic medical conditions is commonly complicated by depression or other psychiatric symptoms. Results reported in studies present a large variation. Thus, synthetic data are needed to understand impact of depression in adults with SCD. The aim of this literature review is to analyse the methodology used in the studies assessing depression and discuss the different prevalence levels reported. Studies involving adults with SCD from 1999 to 2018 were included when providing data on prevalence of depression. It was defined by a psychometric assessment, a structured interview, or a medical record review. PRISMA recommendations were followed. 36 studies are included accordingly to our methodology. Prevalence variation is large, from 0% to more than 85%. We find that the type of assessment tool used plays a major role in this between studies variation. Also, methodological issues arise with respect to psychometric assessment. Moreover, differences emerge between continents, setting of recruitment or time of assessment. All these issues are discussed to provide insight on depression in adults with sickle cell disease. PROSPERO Registration CRD42018100684.

中文翻译：

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成人镰状细胞疾病患者的抑郁症：评估抑郁症患病率的方法论问题的系统综述

与其他慢性疾病一样，镰状细胞病（SCD）通常会伴有抑郁或其他精神症状。研究报告的结果存在很大差异。因此，需要综合数据来了解抑郁症对患有SCD的成年人的影响。这篇文献综述的目的是分析评估抑郁症的研究中使用的方法，并讨论所报道的不同患病率。提供有关抑郁症患病率的数据时，纳入了1999年至2018年涉及SCD的成年人的研究。它是通过心理评估，结构化访谈或病历审查来定义的。遵循了PRISMA的建议。我们的方法包括36个研究。患病率差异很大，从0％到超过85％。我们发现所使用的评估工具的类型在不同研究之间对此起主要作用。而且，关于心理测评的方法学问题也出现了。此外，各大洲，征聘背景或评估时间之间也存在差异。讨论了所有这些问题，以提供有关镰状细胞病成人抑郁症的见识。PROSPERO注册CRD42018100684。