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MrgprC11+ sensory neurons mediate glabrous skin itch [Neuroscience]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.412 ) Pub Date : 2021-04-13 , DOI: 10.1073/pnas.2022874118
Haley R. Steele, Yanyan Xing, Yuyan Zhu, Henry B. Hilley, Katy Lawson, Yeseul Nho, Taylor Niehoff, Liang Han

Itch arising from glabrous skin (palms and soles) has attracted limited attention within the field due to the lack of methodology. This is despite glabrous itch arising from many medical conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis. Therefore, we developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch. Our results show that MrgprA3+ and MrgprD+ neurons, although key mediators for hairy skin itch, do not play important roles in glabrous skin itch, demonstrating a mechanistic difference in itch sensation between hairy and glabrous skin. We found that MrgprC11+ neurons are the major mediators for glabrous skin itch. Activation of MrgprC11+ neurons induced glabrous skin itch, while ablation of MrgprC11+ neurons reduced both acute and chronic glabrous skin itch. Our study provides insights into the mechanisms of itch and opens up new avenues for future glabrous skin itch research.



中文翻译:

MrgprC11 +感觉神经元介导无毛的皮肤瘙痒[神经科学]

由于缺乏方法,无毛的皮肤(手掌和脚底)引起的瘙痒在该领域引起了有限的关注。尽管存在由于许多医疗状况(例如足底和掌状牛皮癣,汗液干少和胆汁淤积)而引起的无痒感。因此,我们开发了一种小鼠无毛皮肤行为测定法,以调查三个先前确定的无毛感觉神经元在无毛皮肤瘙痒中的作用。我们的研究结果表明,MgrgprA3 +和MrgprD +神经元尽管是毛发皮肤瘙痒的关键介体,但在无毛皮肤瘙痒中并不发挥重要作用,这说明了毛发和无毛皮肤之间的痒感机理存在差异。我们发现MrgprC11 +神经元是皮肤瘙痒的主要介质。MrgprC11 +神经元的激活可引起皮肤瘙痒,而消融MrgprC11 +神经元可减少急性和慢性皮肤无痒感。我们的研究为瘙痒的机理提供了见识,并为将来的无痕皮肤瘙痒研究开辟了新途径。

更新日期:2021-04-06
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