Objective

To compare the performance of the dry eye questionnaire (DEQ-5) with the Ocular Surface Disease Index (OSDI) and further validate the DEQ-5 questionnaire.

Methods

A population-based cross-sectional study conducted in Ghana. OSDI and DEQ-5 questionnaires were administered to participants. Cronbach’s alpha was used to evaluate the reliability of the OSDI and DEQ-5 questionnaires. Analysis of variance was used to evaluate the discriminant validity of DEQ-5. Concurrent validity was evaluated using the Spearman correlation analysis. A receiver operating characteristic (ROC) curve was generated to describe the sensitivity and specificity of the DEQ-5 questionnaire for diagnosis of dry eye symptoms. Cohen Kappa was used to evaluate agreement between the two questionnaires.

Results

The reliability of the overall OSDI and DEQ-5 scores were 0.919 and 0.819 respectively. The mean (SD) DEQ-5 scores for asymptomatic, mild, moderate and severe dry eye symptoms as defined by the OSDI grading were 3.05 (2.73), 5.13 (3.69), 7.65 (3.30) and 9.77 (4.16) respectively. There was a statistically significant correlation between total OSDI and total DEQ-5 scores (r_s = 0.649, p < 0.0001). The area under the curve (AUC) of the ROC curve for DEQ-5 was 0.835 (95 % CI: 0.796 – 0.875). A DEQ-5 threshold of 5.5 yielded maximum sensitivity (0.712) and specificity (0.827). The Cohen kappa using a the DEQ-5 total score threshold of 5.5 was K = 0.539 (p < 0.0001).

Conclusion

In conclusion, performance of the DEQ-5 questionnaire in discriminating symptoms of dry eye is comparable to the OSDI questionnaire. The DEQ-5 questionnaire is a valid measure of dry eye symptoms and can be used as a dry eye symptoms assessment tool in both clinical and epidemiological studies.

中文翻译：

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干眼问卷 (DEQ-5) 与非临床人群眼表疾病指数表现的比较

客观的

比较干眼问卷 (DEQ-5) 与眼表疾病指数 (OSDI) 的表现，并进一步验证 DEQ-5 问卷。

方法

在加纳进行的一项基于人群的横断面研究。对参与者进行了 OSDI 和 DEQ-5 问卷调查。Cronbach's alpha 用于评估 OSDI 和 DEQ-5 问卷的可靠性。方差分析用于评估 DEQ-5 的区分效度。使用 Spearman 相关分析评估同时效度。生成受试者工作特征 (ROC) 曲线来描述 DEQ-5 问卷诊断干眼症状的敏感性和特异性。Cohen Kappa 用于评估两个问卷之间的一致性。

结果

总体 OSDI 和 DEQ-5 评分的可靠性分别为 0.919 和 0.819。由 OSDI 分级定义的无症状、轻度、中度和重度干眼症状的平均 (SD) DEQ-5 评分分别为 3.05 (2.73)、5.13 (3.69)、7.65 (3.30) 和 9.77 (4.16)。总 OSDI 和总 DEQ-5 分数之间存在统计学显着相关性（r _s = 0.649，p < 0.0001）。DEQ-5 ROC 曲线的曲线下面积 (AUC) 为 0.835 (95 % CI: 0.796 – 0.875)。5.5 的 DEQ-5 阈值产生最大灵敏度 (0.712) 和特异性 (0.827)。使用 DEQ-5 总分阈值为 5.5 的 Cohen kappa 为 K = 0.539 (p < 0.0001)。

结论

总之，DEQ-5 问卷在区分干眼症状方面的表现与 OSDI 问卷相当。DEQ-5 问卷是干眼症状的有效量度，可用作临床和流行病学研究中的干眼症状评估工具。