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Accelerator Production Method in 140 Nd/ 140 Pr Radioisotope Generator Based on Electron Capture
Brazilian Journal of Physics ( IF 1.6 ) Pub Date : 2021-04-05 , DOI: 10.1007/s13538-021-00858-y
Ozan Artun

140Nd/140Pr radioisotope generator has importance for cancer diagnosis purposes and promises as an in vivo generator in positron emission tomography (PET). 140Nd/140Pr radioisotope generator is based on physicochemical processes, such as electron capture (EC), between parent (140Nd) and daughter (140Pr) radioisotopes. The production of the parent 140Nd radioisotope was performed by particle accelerators using charged particle induced reaction processes for energy region of Eparticle = 100 → 1 MeV in irradiation time of 1 h with constant beam current of 1 µA. In addition to the production of the parent 140Nd radioisotope, we also considered the direct production of 140Pr radioisotope via particle accelerators at the same conditions because 140Pr radioisotope in low-budget facilities can be directly used in PET scans such as in hospitals due to its short half-life. Hence, the cross-section and integral yield curves of reaction processes were calculated as dependent on projectile energies, and activities and yields of products were simulated. The obtained results were compared with the experimental data in the literature and provided new nuclear data to the literature which lead to the experimentalist.



中文翻译:

基于电子俘获的140 Nd / 140 Pr放射性同位素发生器的加速剂生产方法

140 Nd / 140 Pr放射性同位素发生器对于癌症诊断具有重要意义,并有望作为正电子发射断层扫描(PET)中的体内发生器。140 Nd / 140 Pr放射性同位素生成器基于父(140 Nd)和子(140 Pr)放射性同位素之间的物理化学过程,例如电子捕获(EC)。母体140 Nd放射性同位素的生产是通过粒子加速器进行的,使用带电粒子诱导的反应过程, 在1 h的照射时间内,在1 µA的恒定束流下,E粒子的能量区域= 100→1 MeV。除了父母140的生产Nd放射性同位素,我们还考虑了在相同条件下通过粒子加速器直接生产140 Pr放射性同位素的原因,因为低预算设施中的140 Pr放射性同位素由于其半衰期短而可以直接用于PET扫描,例如医院。因此,根据弹丸能量计算反应过程的横截面和积分产率曲线,并模拟产物的活性和产率。将获得的结果与文献中的实验数据进行比较,并为文献提供了新的核数据,这为实验者提供了可能。

更新日期:2021-04-05
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