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Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
Pure and Applied Chemistry ( IF 1.8 ) Pub Date : 2021-03-01 , DOI: 10.1515/pac-2018-0208
Paul Erhardt 1 , Kenneth Bachmann 2 , Donald Birkett 3 , Michael Boberg 4 , Nicholas Bodor 5 , Gordon Gibson 6 , David Hawkins 7 , Gabrielle Hawksworth 8 , Jack Hinson 9 , Daniel Koehler 10 , Brian Kress 11 , Amarjit Luniwal 12 , Hiroshi Masumoto 13 , Raymond Novak 14 , Phillip Portoghese 15 , Jeffrey Sarver 10 , M. Teresa Serafini 16 , Christopher Trabbic 17 , Nico Vermeulen 18 , Steven Wrighton 19
Affiliation  

This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta- testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today’s highly multidisciplinary, collaborative small molecule drug discovery teams.

中文翻译:

在小分子药物发现和开发过程中使用的异种代谢术语词汇表和教程(IUPAC技术报告)

该项目始于15年前,旨在产生药物代谢术语的词汇表,该词汇表的定义特别适用于执业药物化学家。第一个草案版本进行了广泛的beta测试,该测试很幸运地使国际观众参与了涉及药物发现和开发的广泛学科。显然,在这些参与者中纳入信息以加强讨论将更加有价值。当前版本保留了化学结构主题,同时扩展了教程注释,旨在弥合跨学科交流某个给定术语时可能出现的各种观点。本词汇表旨在对早期研究人员进行教育,
更新日期:2021-04-05
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