Intrinsic radioresistance and increased proliferation rates in head and neck cancers (HNCs) are associated with negative radiotherapy (RT) treatment responses. The use of gold nanoparticles (AuNPs) as radiosensitizers could enable total radiation dose reduction and lowered radiation toxicity. AuNP radiosensitization may overcome hypoxia-induced radioresistance and treatment-induced accelerated repopulation of cancer cells in HNCs, improving radiotherapy outcomes.

中文翻译：

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金纳米粒子放射增敏分次放疗期间缺氧头颈癌的预测模型

头颈癌 (HNC) 的固有放射抗性和增殖率增加与放疗 (RT) 治疗反应呈阴性有关。使用金纳米粒子 (AuNPs) 作为放射增敏剂可以减少总辐射剂量并降低辐射毒性。AuNP放射增敏可能克服缺氧诱导的放射抗性和治疗诱导的HNCs癌细胞加速增殖，改善放疗结果。