The present report describes a case of cutaneous papillomatosis related to equine papillomavirus type 2 (EcPV2) with concomitant cutaneous habronemiasis. A 2-year-old female Pura Raza Española horse was referred for a dermatological evaluation because of the onset of cutaneous multifocal, nodular lesions on the face characterised by a warty and partially ulcerated overlying epidermis. Multiple biopsies were taken from these lesions, and cutaneous viral papillomas with a concomitant severe focal eosinophilic dermatitis with intralesional Habronematidae nematode larvae were diagnosed. Immunohistochemistry revealed papillomaviral capsid protein L1 in the epidermal proliferative lesion, confirming the presence of a productive infection. Rt-qPCR confirmed the presence of EcPV type 2. To the authors’ knowledge, this is the first report of EcPV2-related papillomas with concurrent habronemiasis.

中文翻译：

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与 Equus caballus papillomavirus 2 型相关的乳头状瘤与皮肤缺氧症的共同发生

本报告描述了与马乳头瘤病毒 2 型 (EcPV2) 相关的皮肤乳头状瘤病病例，并伴有皮肤缺氧血症。一匹 2 岁的雌性 Pura Raza Española 马被转诊进行皮肤病学评估，因为面部皮肤出现多灶性结节性病变，其特征是覆盖在表皮上的疣和部分溃疡。从这些病变处进行了多次活检，诊断出皮肤病毒性乳头状瘤伴有严重的局灶性嗜酸性皮炎和病灶内 Habronematidae 线虫幼虫。免疫组织化学显示表皮增殖性病变中存在乳头瘤病毒衣壳蛋白 L1，证实存在生产性感染。Rt-qPCR 证实了 EcPV 2 型的存在。据作者所知，