SummaryMedically assisted reproductive (MAR) treatments using donated oocytes are commonly applied in several countries to treat women who cannot conceive with their own gametes. Historically, in Italy, gamete donation has been prohibited but, in 2014, the law changed and gamete donation became allowed for couples undergoing MAR treatments. Consequently, in the last decade, there has been an increase in application of the oocyte donation programme. This study reports an egg-donation programme’s clinical efficacy, based on importing donated vitrified oocytes from cryo-banks located in a foreign country. For this, we conducted a retrospective analysis of data from a single reproductive unit located in Italy (Donna Salus Women’s Health and Fertility, Bozen). The study group consisted of 681 vitrified oocytes, which were warmed and culture to be replaced in 100 recipients. The survival rate after warming was 79.1% (n = 539/681), whereas the fertilization and blastulation rates were 90.2% (n = 486/539) and 47.9% (n = 233/486), respectively. Positive pregnancy test, clinical pregnancy rates, and live-birth rates per embryo transfer were 37.8%, 31.1% and 28.4%, respectively. The multiple pregnancy rate was 0.7%. This study is one of the first to report on the efficacy of a donor oocyte programme in Italy using imported vitrified oocytes. The above data may reassure women who are undertaking donation programmes using vitrified oocytes imported from commercial egg banks.

中文翻译：

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玻璃化加热供体卵母细胞计划的活产和临床结果：单个体外受精单元的经验

摘要使用捐赠的卵母细胞的医学辅助生殖 (MAR) 治疗通常在几个国家用于治疗无法用自己的配子怀孕的女性。从历史上看，在意大利，配子捐赠一直是被禁止的，但在 2014 年，法律发生了变化，并且允许接受 MAR 治疗的夫妇捐赠配子。因此，在过去十年中，卵母细胞捐赠计划的应用有所增加。本研究报告了一项卵子捐赠计划的临床疗效，该计划基于从位于外国的冷冻库进口捐赠的玻璃化卵母细胞。为此，我们对位于意大利的单个生殖单位（Donna Salus Women's Health and Fertility, Bozen）的数据进行了回顾性分析。该研究组由 681 个玻璃化卵母细胞组成，对 100 名受者进行加热并更换培养物。升温后成活率为79.1%（n= 539/681), 而受精率和囊胚率为 90.2% (n= 486/539) 和 47.9% (n= 233/486），分别。妊娠试验阳性率、临床妊娠率和每次胚胎移植的活产率分别为 37.8%、31.1% 和 28.4%。多胎妊娠率为0.7%。这项研究是最早报告意大利使用进口玻璃化卵母细胞的捐赠卵母细胞计划效果的研究之一。上述数据可以让使用从商业卵子库进口的玻璃化卵母细胞进行捐赠计划的女性放心。