Porous zinc oxide has good application prospects as one of the new antibiotic alternatives. Research on its synthesis and antimicrobial evaluation has attracted more and more attentions in recent years. In our study, a new kind of porous zinc oxide was synthesized by a hydrothermal method using β-cyclodextrin as organic small molecular template. Characterization of structure and morphology showed that the new porous zinc oxide was naturally agglomerated and exhibited microsphere morphologies with diameters of 1-2 μm, which were assembled from two-dimensional nanosheets. Furthermore, the antimicrobial activity of porous zinc oxide was evaluated in vitro and in vivo. For Escherichia coli and Staphylococcus aureus inhibition experiments, the antimicrobial effect of porous zinc oxide was similar with nano zinc oxide at the same concentration. Additionally, the weanling piglets experiment lasted for 14 days to evaluate growth performance and diarrhea rate. Results showed that feed conversion ratio was improved significantly in 1,000 mg/kg porous zinc oxide group and 400 mg/kg chlortetracycline group compared with 3,000 mg/kg ordinary-size zinc oxide and 500 mg/kg porous zinc oxide treatments in the whole experiment period (P<0.05). Diarrhea rates in the 1,000 mg/kg porous zinc oxide group and 400 mg/kg chlortetracycline group were also substantially lower than those of 3,000 mg/kg ordinary-size zinc oxide and 500 mg/kg porous zinc oxide treatments (P<0.05). In conclusion, the new porous zinc oxide has a typical agglomerated and porous structure, and has superior antimicrobial activity versus ordinary-size zinc oxide. These novel findings provide solid data to support the application of porous zinc oxide in piglet husbandry.

多孔氧化锌作为新型抗生素替代品之一具有良好的应用前景。近年来，有关其合成和抗菌评价的研究受到越来越多的关注。在我们的研究中，以β-环糊精为有机小分子模板，通过水热法合成了一种新型的多孔氧化锌。结构和形态的表征表明，新的多孔氧化锌是自然团聚的，并表现出直径为1-2μm的微球形态，由二维纳米片组装而成。此外，在体外和体内评价了多孔氧化锌的抗微生物活性。用于大肠杆菌和金黄色葡萄球菌抑制实验表明，在相同浓度下，多孔氧化锌的抗菌作用与纳米氧化锌相似。此外，断奶仔猪实验持续了14天，以评估生长性能和腹泻率。结果表明，与整个实验期间的3,000 mg / kg普通大小的氧化锌和500 mg / kg的多孔氧化锌处理相比，1,000 mg / kg的多孔氧化锌组和400 mg / kg的四环素组的饲料转化率显着提高。 （P <0.05）。1,000 mg / kg多孔氧化锌组和400 mg / kg金霉素的腹泻率也大大低于3,000 mg / kg普通大小的氧化锌和500 mg / kg多孔氧化锌的处理（P<0.05）。总之，新型多孔氧化锌具有典型的团聚和多孔结构，并且具有比普通尺寸的氧化锌优越的抗菌活性。这些新颖的发现提供了可靠的数据来支持多孔氧化锌在仔猪饲养中的应用。