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The Selective Dopamine D2 Blocker Sulpiride Modulates the Relationship Between Agentic Extraversion and Executive Functions
Cognitive, Affective, & Behavioral Neuroscience ( IF 2.9 ) Pub Date : 2021-04-02 , DOI: 10.3758/s13415-021-00887-9
Wiebke Herrmann 1 , Jan Wacker 1
Affiliation  

Initial studies suggest that agentic extraversion and executive functions (EF) are associated, because they share influences of individual differences in the dopamine (DA) system. However, it is unclear whether previously reported associations are specific to certain EFs (e.g., to updating or shifting) or due to shared variance among EF tasks. We investigated the DA-related relationship between agentic extraversion and two EF tasks in a placebo-controlled between-group design with the DA D2 receptor blocker sulpiride (200 mg) in 92 female volunteers. Our goals were to investigate whether (1) there is an association between agentic extraversion and EFs measured with two different tasks (3-back and switching), (2) this association is sensitive to a pharmacological manipulation of DA, and (3) the effects can be ascribed to shared or specific task variance. We observed the expected interaction between drug condition and agentic extraversion for both tasks in a multivariate multiple linear regression model, which supports the DA theory of extraversion. Subsequent univariate analyses revealed a highly similar interaction effect between drug condition and agentic extraversion on two of three performance measures and this effect was somewhat attenuated when we controlled for shared task variance. This pattern matches the interpretation that the association between agentic extraversion and both tasks is partly due to DA-based processes shared among the tasks. Our results, although limited by the low reliability of the switching task, suggest that variance components and measurement difficulties of EF tasks should be considered when investigating personality-related individual differences in EFs.



中文翻译:

选择性多巴胺 D2 阻滞剂舒必利调节外向性和执行功能之间的关系

初步研究表明,外向性和执行功能 (EF) 是相关的,因为它们共享多巴胺 (DA) 系统中个体差异的影响。然而,尚不清楚先前报告的关联是否特定于某些 EF(例如,更新或转移)或由于 EF 任务之间的共享差异。我们在 92 名女性志愿者中使用 DA D2 受体阻滞剂舒必利(200 毫克)进行安慰剂对照的组间设计,研究了代理外向性和两个 EF 任务之间的 DA 相关关系。我们的目标是调查 (1) 外向性与使用两种不同任务 (3-back 和转换) 测量的 EFs 之间是否存在关联,(2) 这种关联对 DA 的药理学操作敏感,(3) 效果可归因于共享或特定任务差异。我们在多元多元线性回归模型中观察到药物状况和代理外向性之间的预期相互作用,该模型支持外向性的 DA 理论。随后的单变量分析揭示了药物状况和外向性在三个绩效指标中的两个方面的高度相似的交互作用,当我们控制共享任务方差时,这种影响有所减弱。这种模式符合以下解释,即代理外向性与两个任务之间的关联部分是由于任务之间共享的基于 DA 的过程。我们的结果,虽然受限于切换任务的低可靠性,

更新日期:2021-04-04
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