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Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study
Psychopharmacology ( IF 3.4 ) Pub Date : 2021-04-04 , DOI: 10.1007/s00213-021-05823-w
Toni C Spinella 1 , Sherry H Stewart 1, 2 , Julia Naugler 1 , Igor Yakovenko 1, 2 , Sean P Barrett 1, 2
Affiliation  

Rationale

Cannabidiol (CBD) has been reported to attenuate stress and anxiety, but little is known about the extent to which such effects result from pharmacological versus expectancy factors.

Objectives

We evaluated whether CBD expectancy alone could influence stress, anxiety, and mood, and the extent to which beliefs regarding CBD effects predicted these responses.

Methods

In this randomized crossover study, 43 health adults (23 women) attended two experimental laboratory sessions, where they self-administered CBD-free hempseed oil sublingually. During one session, they were (incorrectly) informed that the oil contained CBD and in the other session, that the oil was CBD-free. Following administration, participants engaged in the Maastricht Acute Stress Test (MAST). Heart rate variability (HRV) was assessed continuously, and subjective state was assessed at baseline, 90-min following oil administration, immediately following the MAST, and after a 10-min recovery period.

Results

The CBD expectancy condition was associated with increased sedation as well as with changes in HRV that were consistent with heightened anticipatory stress regulation. Overall, there were no systematic changes in subjective stress, or anxiety, according to expectancy condition. However, participants who endorsed strong a priori beliefs that CBD has anxiolytic properties reported significantly diminished anxiety in the CBD expectancy condition.

Conclusions

CBD expectancy alone impacted several subjective and physiological responses. Additionally, expectancy-related factors were implicated in anxiolytic effects of CBD for those who believed it was helpful for such purposes, emphasizing the need to measure and control for CBD-related expectancies in clinical research that involves the administration of CBD.



中文翻译:

评估大麻二酚(CBD)对健康成年人急性压力和焦虑的预期影响:一项随机交叉研究

基本原理

据报道,大麻二酚 (CBD) 可以减轻压力和焦虑,但人们对药理因素与预期因素在多大程度上造成这种影响的情况知之甚少。

目标

我们评估了 CBD 预期是否会单独影响压力、焦虑和情绪,以及对 CBD 效应的信念在多大程度上可以预测这些反应。

方法

在这项随机交叉研究中,43 名健康成年人(23 名女性)参加了两次实验实验室课程,他们自行舌下含服不含 CBD 的大麻籽油。在一次会议中,他们(错误地)被告知该油含有 CBD,而在另一次会议中,他们被告知该油不含 CBD。给药后,参与者进行了马斯特里赫特急性压力测试(MAST)。连续评估心率变异性 (HRV),并在基线、给药后 90 分钟、MAST 后立即以及 10 分钟恢复期后评估主观状态。

结果

CBD 预期状况与镇静作用的增加以及 HRV 的变化有关,而 HRV 的变化与预期压力调节的增强一致。总体而言,根据预期条件,主观压力或焦虑没有发生系统性变化。然而,那些强烈支持CBD 具有抗焦虑特性的先验信念的参与者报告说,CBD 预期条件下的焦虑显着减少。

结论

仅 CBD 预期就影响了一些主观和生理反应。此外,对于那些认为 CBD 有助于达到此目的的人来说,与预期相关的因素与 CBD 的抗焦虑作用有关,强调需要在涉及 CBD 管理的临床研究中测量和控制 CBD 相关的预期。

更新日期:2021-04-04
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