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Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet
Adipocyte ( IF 3.3 ) Pub Date : 2021-04-02 , DOI: 10.1080/21623945.2021.1906510
Liang Xu 1, 2 , Dandan Li 1 , Yuqin Zhu 1 , Suili Cai 1 , Xue Liang 1 , Ying Tang 1 , Shengnan Jin 1, 2 , Chunming Ding 1, 2
Affiliation  

ABSTRACT

Obesity is characterized by low-grade chronic inflammation, which underlies insulin resistance and non-alcoholic fatty liver disease (NAFLD). Swertiamarin is a secoiridoid glycoside that has been reported to ameliorate diabetes and NAFLD in animal models. However, the effects of swertiamarin on obesity-related inflammation and insulin resistance have not been fully elucidated. Thus, this study investigated the effects of swertiamarin on inflammation and insulin resistance in high-fat diet (HFD)-induced obese mice. C57BL/6 mice were fed a HFD or HFD containing swertiamarin for 8 weeks. Obesity-induced insulin resistance and inflammation were assessed in the epididymal white adipose tissue (eWAT) and livers of the mice. Swertiamarin attenuated HFD-induced weight gain, glucose intolerance, oxidative stress, and insulin resistance, and enhanced insulin signalling in mice. Compared to HFD-fed mice, the swertiamarin-treated mice exhibited increased lipolysis and reduced adipocyte hypertrophy and macrophage infiltration in eWAT. Moreover, swertiamarin alleviated HFD-mediated hepatic steatosis and inflammation by suppressing activation of the p38 MAPK and NF-κB pathways within the eWAT and liver of obese mice. In conclusion, supplementation with swertiamarin attenuated weight gain and hepatic steatosis, and alleviated obesity-associated inflammation and insulin resistance, in obese mice.



中文翻译:

Swertiamarin 补充剂可预防高脂饮食小鼠与肥胖相关的慢性炎症和胰岛素抵抗

摘要

肥胖的特征是轻度慢性炎症,这是胰岛素抵抗和非酒精性脂肪肝 (NAFLD) 的基础。Swertiamarin 是一种类环烯醚萜苷,据报道可在动物模型中改善糖尿病和 NAFLD。然而,芥末素对肥胖相关炎症和胰岛素抵抗的影响尚未完全阐明。因此,本研究调查了芥子素对高脂饮食 (HFD) 诱导的肥胖小鼠炎症和胰岛素抵抗的影响。C57BL/6 小鼠喂食 HFD 或含有 swertiamarin 的 HFD 8 周。在小鼠的附睾白色脂肪组织 (eWAT) 和肝脏中评估了肥胖引起的胰岛素抵抗和炎症。Swertiamarin 减弱了 HFD 引起的体重增加、葡萄糖耐受不良、氧化应激和胰岛素抵抗,并增强小鼠的胰岛素信号。与喂食 HFD 的小鼠相比,用 swertiamarin 处理的小鼠在 eWAT 中表现出增加的脂肪分解和减少的脂肪细胞肥大和巨噬细胞浸润。此外,swertiamarin 通过抑制肥胖小鼠 eWAT 和肝脏内 p38 MAPK 和 NF-κB 通路的激活,减轻了 HFD 介导的肝脏脂肪变性和炎症。总之,在肥胖小鼠中,补充芥子素可减轻体重增加和肝脂肪变性,并减轻与肥胖相关的炎症和胰岛素抵抗。swertiamarin 通过抑制肥胖小鼠 eWAT 和肝脏内 p38 MAPK 和 NF-κB 通路的激活,减轻了 HFD 介导的肝脏脂肪变性和炎症。总之,在肥胖小鼠中,补充芥子素可减轻体重增加和肝脂肪变性,并减轻与肥胖相关的炎症和胰岛素抵抗。swertiamarin 通过抑制肥胖小鼠 eWAT 和肝脏内 p38 MAPK 和 NF-κB 通路的激活,减轻了 HFD 介导的肝脏脂肪变性和炎症。总之,在肥胖小鼠中,补充芥子素可减轻体重增加和肝脏脂肪变性,并减轻与肥胖相关的炎症和胰岛素抵抗。

更新日期:2021-04-02
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