当前位置: X-MOL 学术Cancer Epidemiol. Biomarkers Prev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A Prospective Investigation of Circulating Metabolome Identifies Potential Biomarkers for Gastric Cancer Risk
Cancer Epidemiology, Biomarkers & Prevention ( IF 3.8 ) Pub Date : 2021-09-01 , DOI: 10.1158/1055-9965.epi-20-1633
Xiang Shu 1, 2 , Hui Cai 1 , Qing Lan 3 , Qiuyin Cai 1 , Bu-Tian Ji 3 , Wei Zheng 1 , Xiao-Ou Shu 1
Affiliation  

Background: Metabolomics is widely used to identify potential novel biomarkers for cancer risk. No investigation, however, has been conducted to prospectively evaluate the role of perturbation of metabolome in gastric cancer development. Methods: 250 incident cases diagnosed with primary gastric cancer were selected from the Shanghai Women’s Health and the Shanghai Men’s Health Study, and each was individually matched to one control by incidence density sampling. An untargeted global profiling platform was used to measure approximately 1,000 metabolites in prediagnostic plasma. Conditional logistic regression was utilized to generate ORs and P values. Results: Eighteen metabolites were associated with gastric cancer risk at P < 0.01. Among them, 11 metabolites were lysophospholipids or lipids of other classes; for example, 1-(1-enyl-palmitoyl)-GPE (P-16:0) (OR = 1.56; P = 1.89 × 10–4). Levels of methylmalonate, a suggested biomarker of vitamin B12 deficiency, was correlated with increased gastric cancer risk (OR = 1.42; P = 0.004). Inverse associations were found for three biomarkers for coffee/tea consumption (3-hydroxypyridine sulfate, quinate and N-(2-furoyl) glycine), although the associations were only significant when comparing cases that were diagnosed within 5 years after the blood collection to matched controls. Most of the identified associations were more profound in women and never smokers than their male or ever smoking counterparts and some with notable significant interactions. Conclusions: Our study identified multiple potential risk biomarkers for gastric cancer independent of Helicobacter pylori infection and other major risk factors. Impact: New risk-assessment tools to identify high-risk population could be developed to improve prevention of gastric cancer. See related commentary by Drew et al., [p. 1601][1] This article is featured in Highlights of This Issue, [p. 1599][2] [1]: /lookup/volpage/30/1601?iss=9 [2]: /lookup/volpage/30/1599?iss=9

中文翻译:

循环代谢组的前瞻性研究确定了胃癌风险的潜在生物标志物

背景:代谢组学被广泛用于识别癌症风险的潜在新型生物标志物。然而,尚未进行任何研究来前瞻性地评估代谢组扰动在胃癌发展中的作用。方法:从上海妇女健康和上海男性健康研究中选择250例原发性胃癌发病病例,并通过发病密度抽样将每个病例单独匹配到一个对照。使用非靶向全局分析平台测量诊断前血浆中的大约 1,000 种代谢物。条件逻辑回归用于生成 OR 和 P 值。结果:18 种代谢物与胃癌风险相关,P < 0.01。其中,11种代谢物为溶血磷脂或其他类脂;例如,1-(1-烯基-棕榈酰)-GPE (P-16:0) (OR = 1.56; P = 1.89 × 10-4)。丙二酸甲酯水平是维生素 B12 缺乏的一种建议生物标志物,与胃癌风险增加相关(OR = 1.42;P = 0.004)。发现咖啡/茶消费的三种生物标志物(3-羟基吡啶硫酸盐、奎宁酸盐和 N-(2-糠酰)甘氨酸)呈负相关,尽管仅在将采血后 5 年内诊断的病例与匹配的控件。大多数已确定的关联在女性和从不吸烟者中比在男性或曾经吸烟的同行中更为深刻,并且有些关联具有显着的显着相互作用。结论:我们的研究确定了胃癌的多种潜在风险生物标志物,与幽门螺杆菌感染和其他主要风险因素无关。影响:可以开发新的风险评估工具来识别高危人群,以改善胃癌的预防。参见 Drew 等人的相关评论,[p. 1601][1] 这篇文章被收录在本期的亮点中,[p. 1599][2] [1]:/lookup/volpage/30/1601?iss=9 [2]:/lookup/volpage/30/1599?iss=9
更新日期:2021-09-02
down
wechat
bug