Transition-metal catalysis provides new approaches to selectivity and the activation of otherwise inert functional groups. Bioconjugation with protein and peptide substrates presents numerous challenges of functional group activation and selectivity, and transitional-metal approaches provide important alternative solutions to these challenges. This article describes the development of boronic acid reagents for new selective approaches to modification of peptides and proteins, focusing primarily on catalytic C−X bond formation.

中文翻译：

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用于过渡金属介导的蛋白质和肽交叉偶联的硼酸试剂

过渡金属催化为选择性和活化惰性官能团提供了新方法。与蛋白质和肽底物的生物偶联提出了功能基团激活和选择性方面的众多挑战，过渡金属方法为这些挑战提供了重要的替代解决方案。本文描述了用于修饰肽和蛋白质的新选择性方法的硼酸试剂的开发，主要侧重于催化 C-X 键的形成。